gene

RPS21

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPS21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

8Outgoing

0Incoming

0Experiments

0Debates

Summary

RPS21: ribosomal protein S21, 40S subunit component, role in neuronal translation, neurodegenerative disease associations, and therapeutic potential

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🧬 Gene Info

Gene Symbol	RPS21
Full Name	Ribosomal Protein S21
Chromosome	21q22.3
Primary Expression	neurons, astrocytes, and microglia, where it supports the high protein synthesis demands required for synaptic function, axonal transport, and cellula
Molecular Weight	9.1 kDa
Amino Acids	83 aa
Exons	3
Pathways	MAPK
UniProt ID	P63220
NCBI Gene ID	6157
GeneCards	RPS21
Human Protein Atlas	RPS21
Associated Diseases	neurodegeneration
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RPS21 — AlphaFold P63220 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RPS21 — Ribosomal Protein S21

gene · 1489 words

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Pathway Diagram

graph TD
    RPS21["RPS21"]
    MAPK(["MAPK"])
    RPS21 -->|"regulates"| MAPK
    cell_proliferation["cell proliferation"]
    RPS21 -->|"inhibits"| cell_proliferation
    cell_migration["cell migration"]
    RPS21 -->|"inhibits"| cell_migration
    cell_invasion["cell invasion"]
    RPS21 -->|"inhibits"| cell_invasion
    n_18S_rRNA_maturation["18S rRNA maturation"]
    RPS21 -->|"participates in"| n_18S_rRNA_maturation
    n_40S_ribosomal_subunit_formation["40S ribosomal subunit formation"]
    RPS21 -->|"participates in"| n_40S_ribosomal_subunit_formation
    EIF_2_signaling_pathway(["EIF-2 signaling pathway"])
    RPS21 -->|"participates in"| EIF_2_signaling_pathway
    GPX4["GPX4"]
    RPS21 -->|"stabilizes"| GPX4
    neurodegeneration["neurodegeneration"]
    RPS21 -->|"implicated in"| neurodegeneration
    style RPS21 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
40S ribosomal subunit formation	participates_in	biological_process	0.80
cell migration	inhibits	phenotype	0.80
cell invasion	inhibits	phenotype	0.80
cell proliferation	inhibits	phenotype	0.80
18S rRNA maturation	participates_in	biological_process	0.80
MAPK	regulates	pathway	0.80
EIF-2 signaling pathway	participates_in	pathway	0.70
GPX4	stabilizes	gene	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPS21 in their description or question text

No additional research found