protein

RPL9PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPL9PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The ribosomal machinery is fundamental to cellular protein homeostasis (proteostasis), and disruption of this system has been increasingly recognized as a key contributor to neurodegeneration.

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🔬 Protein Info

Gene Symbol	RPL9PROTEIN
Chromosome	4p13
Function	is a component of the 60S large ribosomal subunit in eukaryotic cells.
Subcellular Localization	</th><td>Cytoplasm, ribosome</td></tr>
GeneCards	RPL9PROTEIN
Human Protein Atlas	RPL9PROTEIN
RNA-binding domain	RPL9 contains domains that facilitate binding to the 28S rRNA of the 60S subunit
Alpha-helical structure	The protein has a characteristic alpha-helical structure typical of many ribosomal proteins
Peptidyl transferase center proximity	RPL9 is positioned near the peptidyl transferase center, where peptide bond formation occurs
tRNA interaction sites	The protein contributes to stabilizing tRNA binding at the P-site of the ribosome
tRNA stabilization	RPL9 helps stabilize the binding of peptidyl-tRNA at the P-site, which is critical for the accuracy and efficiency of translation
Ribosome assembly	RPL9 participates in the assembly of the 60S subunit, integrating with rRNA and other ribosomal proteins to form a functional ribosomal particle
Axonal translation	mRNAs are transported to distal neuronal compartments, including growth cones and synaptic terminals, requiring coordinated ribosomal activity for local protein synthesis
Protein homeostasis disruption	The accumulation of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles is associated with impaired protein quality control systems, including the ribosome
Synaptic ribosomal dysfunction	Synaptic compartments are particularly vulnerable to ribosomal dysfunction, contributing to synaptic loss and cognitive decline in AD
Associated Diseases	neurodegeneration
Interactions	EIF4G2
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ribosomal Protein L9

protein · 1145 words

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Pathway Diagram

graph TD
    RPL9PROTEIN["RPL9PROTEIN"]
    neurodegeneration["neurodegeneration"]
    RPL9PROTEIN -->|"implicated_in"| neurodegeneration
    style RPL9PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning RPL9PROTEIN in their description or question text

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