Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPL9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RPL9 |
| Function | encodes a ribosomal protein component of the 60S large ribosomal subunit. |
| Primary Expression | various brain regions |
| Molecular Weight | 22 kDa |
| Amino Acids | 192 aa |
| Ensembl ID | ENSG00000163682 |
| GeneCards | RPL9 |
| Human Protein Atlas | RPL9 |
| Protein synthesis | Contributes to peptide bond formation at the peptidyl transferase center |
| Ribosome assembly | Essential for proper 60S subunit biogenesis |
| rRNA interaction | Interacts with 28S rRNA to stabilize the large subunit |
| Translation termination | Participates in the release factor binding site |
| N-terminal domain | Contains RNA-binding regions |
| Central region | Involved in protein-protein interactions |
| Surface localization | Positioned to interact with both ribosomal proteins and extraribosomal factors |
| Associated Diseases | neurodegeneration |
| Interactions | EIF4G2 |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["RPL9"]
N1["EIF4G2"]
N1 -->|"interacts with"| N0
N2["neurodegeneration"]
N0 -->|"implicated in"| N2
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| EIF4G2 | interacts_with | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RPL9 in their description or question text
No additional research found