Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPL15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RPL15 |
| Chromosome | 12q24.31. |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | Predominantly cytoplasmic, associated with the 60S ribosomal subunit |
| Molecular Weight | Approximately 24.2 kDa |
| Amino Acids | 204 amino acids |
| GeneCards | RPL15 |
| Human Protein Atlas | RPL15 |
| Isoforms | Multiple isoforms identified through alternative splicing |
| Domain Structure | Contains ribosomal protein L27 domain involved in peptidyl transferase activity |
| 60S Subunit Assembly | RPL15 participates in the biogenesis of the 60S ribosomal subunit in the nucleolus |
| Pre-rRNA Processing | The protein interacts with processing factors involved in pre-rRNA cleavage and maturation |
| Nuclear Export | RPL15 assists in the export of mature 60S subunits from the nucleus to the cytoplasm |
| Associated Diseases | Aortic Valve Calcification |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["RPL15"]
N1["Aortic Valve Calcification"]
N0 -->|"associated with"| N1
N2["neurodegeneration"]
N0 -->|"implicated in"| N2
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease| Target | Relation | Type | Str |
|---|---|---|---|
| Aortic Valve Calcification | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RPL15 in their description or question text
No additional research found