Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RNA_binding: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| arginine_methylation | inhibits | mechanism | 0.80 |
| TDP-43 | regulates | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| RNA-binding protein condensate maturation from reversible ph | 0.626 | neurodegeneration | Causal Sequence of TDP-43 Nuclear Cleara |
| RNA-binding protein condensate maturation from reversible ph | 0.626 | neurodegeneration | Biophysical Determinants Shifting FUS/TD |
| RNA-Binding Protein Sequestration and 3′UTR Dysregulation | 0.625 | - | How does the intron-retained RNA isoform |
| RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-m | 0.497 | molecular neurobiology | How does lncRNA-0021 achieve sequence-sp |
| RNA-Binding Competition Therapy for TDP-43 Cross-Seeding | 0.465 | neurodegeneration | Protein aggregation cross-seeding across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 4 hypotheses Top: 0.676
neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.730
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.664
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.720
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TDP-43 mutant mouse model cGAS/STING pathway analysis | validation | amyotrophic lateral sclerosis | 0.900 | 0.00 | TDP-43 mutant mice | proposed | N/A |
| TDP-43 mitochondrial invasion and DNA release via mPTP | exploratory | amyotrophic lateral sclerosis | 0.900 | 0.00 | cultured cells | proposed | N/A |
| TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons | exploratory | Amyotrophic Lateral Sclerosis | 0.900 | 0.00 | iPSC-derived motor neurons | proposed | N/A |
| cGAS/STING pathway validation in TDP-43 mutant mice | validation | Amyotrophic Lateral Sclerosis | 0.850 | 0.00 | TDP-43 mutant mice | proposed | N/A |
| cGAMP biomarker analysis in ALS patient spinal cord samples | exploratory | Amyotrophic Lateral Sclerosis | 0.800 | 0.00 | Human ALS patient spinal cord | proposed | N/A |
| TDP-43 pathology prevalence and distribution in AD cases | exploratory | Alzheimer's disease | 0.800 | 0.00 | human postmortem brain tissue | proposed | N/A |
| Cognitive impact of TDP-43 pathology in AD patients | clinical | Alzheimer's disease | 0.700 | 0.00 | human patients | completed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382] | Meneses A, Koga S, O'Leary J, Dickson DW | Mol Neurodegener | 2021 | 2 |
| Protein transmission in neurodegenerative disease. [PMID:32203399] | Peng C, Trojanowski JQ, Lee VM | Nat Rev Neurol | 2020 | 2 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| ALS-related proteinopathies: From TDP-43 to mitochondrial proteinopathies. [PMID:41570741] | Genin EC, Paquis-Flucklinger V | Current opinion in neurobiolog | 2026 | 0 |
| Refolding-assisted purification of native full-length TDP-43 compatible with BSL [PMID:41692368] | Dehury S, Tiwari S, Los Rios P | Methods | 2026 | 0 |
| Small heat shock proteins HspB1 and HspB5 differentially alter the condensation [PMID:41854301] | Walker TB, Trowbridge JW, McMahon S, Mar | Protein Sci | 2026 | 0 |
| Structural and Mechanistic Heterogeneity of the Phase Separation and Aggregation [PMID:41871974] | Doke AA, Kirmire MS, Jha A, Jha SK | ACS Chem Neurosci | 2026 | 0 |
| The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study [PMID:41883703] | Nassan M, Ayala I, Sloan J, Bonfitto A, | Neurology. Genetics | 2026 | 0 |
| Circular RNAs from the MAPT and TARDBP genes: Novel players in neurodegeneration [PMID:40633584] | ["Bagheri N", "Margvelani G", "Chiang T" | Neurochemistry international | 2025 | 0 |
| Amyotrophic lateral sclerosis caused by TARDBP mutations: from genetics to TDP-4 [PMID:40252666] | Balendra R, Sreedharan J, Hallegger M, L | The Lancet. Neurology | 2025 | 0 |
| TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP- [PMID:34916658] | Xie M, Liu YU, Zhao S, Zhang L, Bosco DB | Nature neuroscience | 2022 | 0 |
| Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339] | Degrave J, Felici F, Buchli J, Neunert M | Nature | 2022 | 0 |
| FUS and TDP-43 Phases in Health and Disease. [PMID:33446423] | ["Portz Bede", "Lee Bo Lim", "Shorter Ja | Trends in biochemical sciences | 2021 | 0 |
| FUS and TDP-43 Phases in Health and Disease. [PMID:33446423] | ["Portz Bede", "Lee Bo Lim", "Shorter Ja | Trends in biochemical sciences | 2021 | 0 |
| Cardiomyocyte-derived calcitonin regulates atrial fibrosis and AF. [PMID:33199879] | Fernández-Ruiz I | Nature reviews. Cardiology | 2021 | 0 |
| SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center. [PMID:34469734] | Ou P, Stanek A, Huan Z, Roman CAJ, Huan | Cell reports | 2021 | 0 |
| TDP-43 condensation properties specify its RNA-binding and regulatory repertoire [PMID:34380047] | Hallegger M, Chakrabarti AM, Lee FCY, Le | Cell | 2021 | 0 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 0 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298] | Melamed Ze'ev; López-Erauskin Jone; | Nature neuroscience | 2019 | 0 |
| Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-de [PMID:30643298] | Melamed Z, López-Erauskin J, Baughn MW, | Nature neuroscience | 2019 | 0 |
Multi-agent debates referencing this entity
active · Rounds: 4 · Score: 0.67 · 2026-04-28
closed · Rounds: 4 · Score: 0.49 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-25
closed · Rounds: 4 · Score: 0.50 · 2026-04-13
closed · Rounds: 4 · Score: 0.72 · 2026-04-12
closed · Rounds: 4 · Score: 0.88 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning RNA_binding in their description or question text
No additional research found