Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RGFP966: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | RGFP966 |
| Key Genes/Proteins | CDX2, HDAC3, HK2 |
| Related Diseases | Cell Migration, Embryo Cleavage Rate, Neurodegeneration, Neurodegenerative Diseases, Reactive Astrocyte |
graph TD
RGFP966[RGFP966]
RGFP966 -->|suppresses| Reactive_Astrocyte[Reactive Astrocyte]
RGFP966 -->|inhibits| HDAC3[HDAC3]
RGFP966 -->|inhibits| Reactive_Astrocyte_Formation[Reactive Astrocyte Formation]
RGFP966 -->|promotes| morula_apoptosis[morula apoptosis]
RGFP966 -->|suppresses| Cell_Migration[Cell Migration]
RGFP966 -->|downregulates| HK2[HK2]
RGFP966 -->|promotes| first_polar_body_extrusion[first polar body extrusion]
RGFP966 -->|suppresses| retinal_endothelial_cell_migra[retinal endothelial cell migration]
RGFP966 -->|promotes| First_Polar_Body_Extrusion[First Polar Body Extrusion]
RGFP966 -->|promotes| Embryo_Cleavage_Rate[Embryo Cleavage Rate]| Target | Relation | Type | Str |
|---|---|---|---|
| HDAC3 | inhibits | protein | 0.95 |
| Reactive Astrocyte | suppresses | phenotype | 0.95 |
| Reactive Astrocyte Formation | inhibits | process | 0.93 |
| morula apoptosis | promotes | phenotype | 0.92 |
| retinal endothelial cell migration | suppresses | phenotype | 0.90 |
| first polar body extrusion | promotes | phenotype | 0.90 |
| Embryo Cleavage Rate | promotes | phenotype | 0.90 |
| Apoptosis | promotes | process | 0.90 |
| First Polar Body Extrusion | promotes | process | 0.90 |
| Cell Migration | suppresses | phenotype | 0.90 |
| HK2 | downregulates | gene | 0.90 |
| H3K27ac | upregulates | protein | 0.88 |
| H3K9me3 | downregulates | protein | 0.88 |
| embryo cleavage rate | associated_with | phenotype | 0.88 |
| CDX2 | upregulates | protein | 0.85 |
| epigenetic reprogramming | associated_with | process | 0.85 |
| Neurodegeneration | protects_against | disease | 0.85 |
| H3K9Me3 | downregulates | biomarker | 0.85 |
| CDX2 | upregulates | gene | 0.85 |
| Neurodegenerative Diseases | treats | disease | 0.85 |
| H3K27Ac | upregulates | biomarker | 0.85 |
| Neuroinflammation | suppresses | process | 0.80 |
| HDAC3 | inhibits | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity