gene

RFNG

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RFNG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RFNG encodes a glycosyltransferase that modifies Notch receptors, playing roles in neurodevelopment and Notch signaling in aging brain.

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🧬 Gene Info

Gene Symbol	RFNG
Full Name	Radical Fringe
Chromosome	17q25.3
Protein Family	Fringe glycosyltransferases
Protein Type	Transferase
Function	encodes a glycosyltransferase that catalyzes the addition of N-acetylglucosamine (GlcNAc) to O-linked fucose residues on Notch receptors.
Primary Expression	the Golgi apparatus of cells during critical windows of neural development
Subcellular Localization	Golgi apparatus: Primary location
Pathways	Notch, Notch signaling, Notch pathway, Notch Signaling
UniProt ID	Q99527
NCBI Gene ID	5996
Ensembl ID	ENSG00000163527
OMIM	602578
GeneCards	RFNG
Human Protein Atlas	RFNG
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RFNG — AlphaFold Q99527 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RFNG — Radical Fringe

gene · 1166 words

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Pathway Diagram

graph TD
    RFNG["RFNG"]
    neurodegeneration["neurodegeneration"]
    RFNG -->|"implicated_in"| neurodegeneration
    style RFNG fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RFNG in their description or question text

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