REM2
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about REM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Regenerate portrait ↻Wiki Pages (20)
Knowledge base pages for this entity
TREM2 Microglial Signaling Pathway in Neurodegeneration
mechanism · 4613 wordsTREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain
mechanism · 3665 wordsTREM2 in Frontotemporal Dementia
mechanism · 3364 wordsTREM2 Signaling in Neurodegeneration
mechanism · 3362 wordsTREM2 in Parkinson's Disease — Cross-Disease Therapeutic Opportunity
mechanism · 3181 wordsOutgoing (2)
| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:REM2 | data_in | dataset_row | 0.00 |
| Neuronal Structure | regulates | phenotype | 0.70 |
Incoming (1)
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:REM2 | data_in | dataset_row | 0.00 |
Targeting Hypotheses (30)
Hypotheses where this entity is a therapeutic target
Mentioning Analyses (21)
Scientific analyses that reference this entity
TREM2 in Alzheimer's Disease: Mechanisms, Therapeutics, and Biomarkers
neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.990
Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other
neurodegeneration | 2026-04-25 | 8 hypotheses Top: 0.640
What is the temporal sequence of TREM2 signaling transition from protective to i
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.672
Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.586
Can biased TREM2 agonists selectively activate DAP12-SYK-PI3K without triggering
molecular biology | 2026-04-12 | 0 hypotheses
Experiments (4)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| NAD depletion effects on monocyte/macrophage differentiation | exploratory | Inflammatory bowel disease | 0.900 | 0.00 | Primary mouse and human monocy | proposed | N/A |
| FK866 treatment in DSS-induced colitis mouse model | validation | Inflammatory bowel disease (co | 0.900 | 0.00 | DSS-induced colitis mice | proposed | N/A |
| FK866 in azoxymethane/DSS colitis-associated cancer model | validation | Colitis-associated cancer | 0.850 | 0.00 | AOM/DSS-treated mice | proposed | N/A |
| FK866 mechanism validation in Rag1-/- mice | validation | Inflammatory bowel disease | 0.850 | 0.00 | Rag1-/- mice with DSS-induced | proposed | N/A |
Related Papers (15)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974] | Dai L, Wang J, Meng L, Zhang X, Xiao T, | PLoS biology | 2025 | 0 |
| Emerging Molecular Targets in Neurodegenerative Disorders: New Avenues for Thera [PMID:40922457] | ["Eroglu E", "Harmanci N"] | Basic & clinical pharmacology | 2025 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | Neuroscientist | 2025 | 0 |
| Microglia, Trem2, and Neurodegeneration. [PMID:38769824] | Shi Q, Gutierrez RA, Bhat MA | The Neuroscientist : a review | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| The role of microglial TREM2 in development: A path toward neurodegeneration? [PMID:38837837] | ["Matteoli Michela"] | Glia | 2024 | 0 |
| TREM2 receptor protects against complement-mediated synaptic loss by binding to [PMID:37442133] | Zhong L, Sheng X, Wang W, Li Y, Zhuo R, | Immunity | 2023 | 0 |
| Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurod [PMID:33603230] | Dong Y, D'Mello C, Pinsky W, Lozinski BM | Nature neuroscience | 2021 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Recent Advances from the Bench Toward the Bedside in Alzheimer's Disease [PMID:26137544] | Macauley SL, Holtzman DM | EBioMedicine | 2015 | 0 |
Debates (20)
Multi-agent debates referencing this entity
Hypothesis debate: PLCG2 Allosteric Modulation as a Precision Therapeutic for TR
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
Hypothesis debate: PLCG2 Allosteric Modulation as a Precision Therapeutic for TR
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
Hypothesis debate: TREM2-Dependent Microglial Senescence Transition
closed · Rounds: 4 · Score: 0.64 · 2026-04-26
Hypothesis debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegene
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
What are the key mechanistic, therapeutic, and diagnostic dimensions of TREM2 in
closed · Rounds: 4 · Score: 0.92 · 2026-04-26
Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other
closed · Rounds: 4 · Score: 0.66 · 2026-04-25
Mechanistic validation of SEA-AD differential expression hypotheses: Complement
closed · Rounds: 0 · Score: 0.66 · 2026-04-21
Mechanistic validation of SEA-AD differential expression hypotheses: Complement
closed · Rounds: 0 · Score: 0.64 · 2026-04-21
Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
Related Research
Hypotheses and analyses mentioning REM2 in their description or question text
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence
Score: 0.893 · neurodegeneration · 2026-04-12
## Mechanistic Overview SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence starts from the claim that modu
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration
Score: 0.892 · neurodegeneration · 2026-04-07
## Mechanistic Overview TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration starts from the claim that mod
TREM2-APOE Axis Dissociation for Selective DAM Activation
Score: 0.886 · neurodegeneration · 2026-04-16
## Mechanistic Overview TREM2-APOE Axis Dissociation for Selective DAM Activation starts from the claim that modulating
TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Faile
Score: 0.862 · neurodegeneration · 2026-04-16
## Mechanistic Overview TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Failed DAM Transition
TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance
Score: 0.861 · neuroscience · 2026-04-12
## Mechanistic Overview TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance starts from the claim
Microglial Senescence Prevention via TREM2/SASP Axis
Score: 0.837 · neurodegeneration · 2026-04-17
## Mechanistic Overview Microglial Senescence Prevention via TREM2/SASP Axis starts from the claim that modulating not y
TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's D
Score: 0.827 · neurodegeneration · 2026-04-26
TREM2 loss-of-function variants impair microglial survival, clustering around amyloid plaques, and phagocytic clearance,
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling
Score: 0.827 · neuroscience · 2026-04-07
## Mechanistic Overview Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling starts from the claim that mod
CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion
Score: 0.808 · neurodegeneration · 2026-04-16
## Mechanistic Overview CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion starts from the claim that modulating
Rare TREM2-TYROBP pathway variants complement standard PRS by identifying microg
Score: 0.000 · Late-onset Alzheimer's disease · 2026-04-26
We hypothesize that rare loss-of-function variants in microglial-expressed genes within the TREM2-TYROBP signaling casca
CSF TREM2 Fragment Ratio Integrated with Neuroinflammatory Cascade Markers
Score: 0.000 · biomarkers · 2026-04-27
Site-specific TREM2 cleavage fragments (N-terminal vs C-terminal ratios) serve as the primary readout for microglial pri
Astrocytic TREM2-Like Receptor Modulation of Synaptic Strengthening Pathways
Score: 0.000 · connectomics · 2026-04-27
This hypothesis proposes that astrocytic TREM2-like receptors (TREML2) regulate synaptic plasticity through a fundamenta
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neuroinflammation
Score: 0.000 · neurodegeneration · 2026-04-27
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neuroinflammation proposes that TREM2 dysfunction disrupts critical in
Plasma TREM2 Ectodomain Glycosylation Patterns as Microglial Senescence Biomarke
Score: 0.000 · biomarkers · 2026-04-27
Site-specific glycosylation patterns on circulating TREM2 ectodomain fragments distinguish senescent from activated micr
Site-Specific TREM2 Fragment Analysis Within Multi-Analyte CSF Panel for Microgl
Score: 0.000 · biomarkers · 2026-04-26
This hypothesis proposes that incorporating Parent B's mechanistically precise site-specific TREM2 fragment ratio analys