Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RASGRP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RASGRP1 encodes a calcium-regulated RAS guanine nucleotide exchange factor that activates RAS/MAPK signaling, with roles in neuronal differentiation, synaptic plasticity, and immune cell development.
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| Gene Symbol | RASGRP1 |
| Chromosome | 5q14.1 |
| Protein Type | Gene |
| Function | is a member of the RasGRP family of calcium-regulated Ras guanine nucleotide exchange factors (GEFs) that play critical roles in activating Ras-MAPK signaling pathways. |
| Primary Expression | both CD4+ and CD8+ T cells, as well as in some B-cell populations and natural killer (NK) cells |
| Amino Acids | 797 aa |
| Exons | 19 |
| Pathways | MAPK signaling, NF-κB |
| UniProt ID | Q9UIJ6 |
| NCBI Gene ID | 10980 |
| Ensembl ID | ENSG00000172575 |
| GeneCards | RASGRP1 |
| Human Protein Atlas | RASGRP1 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["RASGRP1"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RASGRP1 in their description or question text
No additional research found