gene

RAB45

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RAB45: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RAB45 (Ras-related protein Rab-45) - X-linked Rab GTPase involved in intracellular trafficking and neurodevelopmental disorders

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🧬 Gene Info

Gene Symbol	RAB45
Full Name	Ras-Related Protein Rab-45
Chromosome	Xq22.1
Protein Type	Rab GTPase
Function	is a member of the Rab GTPase family encoded by a gene located on the X chromosome at Xq22.1
Primary Expression	Brain, Testis, Ovary, Lung, Liver
Subcellular Localization	### Intracellular Distribution
Amino Acids	704 aa
UniProt ID	Q8WX92
NCBI Gene ID	284308
Ensembl ID	ENSG00000155906
OMIM	300956
GeneCards	RAB45
Human Protein Atlas	RAB45
GxxxxGKST	phosphate-binding loop (P-loop)
Associated Diseases	X-linked neurodevelopmental disorders, Intellectual disability
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAB45 — AlphaFold Q8WX92 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAB45 Gene

gene · 2185 words

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Pathway Diagram

graph TD
    RAB45["RAB45"]
    neurodegeneration["neurodegeneration"]
    RAB45 -->|"implicated_in"| neurodegeneration
    style RAB45 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RAB45 in their description or question text

No additional research found