Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB44: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Rab44 - Unconventional Rab GTPase with multiple domains implicated in intracellular trafficking and neurodegeneration
No AI portrait yet
| Gene Symbol | RAB44 |
| Chromosome | 6p12.3 |
| Function | is a member of the Rab GTPase family, which constitutes the largest branch of the Ras superfamily of small GTPases. |
| Amino Acids | 644 aa |
| Ensembl ID | ENSG00000170312 |
| GeneCards | RAB44 |
| Human Protein Atlas | RAB44 |
| Alternative splicing | Multiple transcript variants have been identified |
| Promoter elements | Contains typical housekeeping promoter features |
| Conservation | Moderately conserved across mammalian species |
| GTPase activating proteins (GAPs) | Inactivate RAB44 by stimulating GTP hydrolysis |
| GDP dissociation inhibitors (GDIs) | Extract and regulate RAB44 localization |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB44["RAB44"]
neurodegeneration["neurodegeneration"]
RAB44 -->|"implicated_in"| neurodegeneration
style RAB44 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RAB44 in their description or question text
No additional research found