Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Purinergic signaling / microglial homeostasis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| P2RY12 | participates_in | gene | 0.46 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Purinergic P2Y12 Inverse Agonist Therapy | 0.703 | neurodegeneration | Synaptic pruning by microglia in early A |
| Microglial Purinergic Reprogramming | 0.701 | neurodegeneration | 4R-tau strain-specific spreading pattern |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.732
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| P2RY12 inhibition in atherosclerosis mouse model | validation | atherosclerosis | 0.900 | 0.00 | ApoE-deficient mice | proposed | N/A |
| VSMC cholesterol efflux and P2RY12 signaling | exploratory | atherosclerosis | 0.900 | 0.00 | cultured VSMCs | proposed | N/A |
| Leukocyte gene expression analysis in COVID-19 patients | exploratory | COVID-19 | 0.900 | 0.00 | human leukocytes from COVID-19 | proposed | N/A |
| P2RY12 regulation of autophagy in VSMCs | exploratory | atherosclerosis | 0.900 | 0.00 | cultured VSMCs | proposed | N/A |
| P2RY12-MTOR pathway interaction in VSMCs | exploratory | atherosclerosis | 0.850 | 0.00 | cultured VSMCs | proposed | N/A |
| In vivo autophagy modulation in atherosclerotic mice | validation | atherosclerosis | 0.850 | 0.00 | ApoE-deficient mice | proposed | N/A |
| s:** - GPR32 knockout in microglia should worsen neuroinflammation if | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on Synaptic pruning by microglia in ea | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $240,000 |
| FTD Microglia Role: Protective vs Destructive Mechanism Study | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Purinergic Signaling Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| DLB Treatment Response Biomarkers — Predicting Cholinesterase Inhibito | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Beyond Activation: Characterizing Microglial Functional Phenotypes. [PMID:34571885] | Lier J, Streit WJ, Bechmann I | Cells | 2021 | 2 |
| The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting auto [PMID:32160082] | Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X | Autophagy | 2021 | 2 |
| Convergence between Microglia and Peripheral Macrophages Phenotype during Develo [PMID:31818979] | Grassivaro F, Menon R, Acquaviva M, Otto | J Neurosci | 2020 | 1 |
| Role of P2Y(12) Receptor in Thrombosis. [PMID:27628007] | Zhang Y, Zhang S, Ding Z | Adv Exp Med Biol | 2017 | 1 |
| P2 purinergic receptors in systemic lupus erythematosus: from experimental findi [PMID:41825304] | Renaudineau Y, Brooks W | Current opinion in immunology | 2026 | 0 |
| Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects [PMID:41924777] | Mroue-Ruiz FH, Desai B, Garvin MM, Shehu | Biochemical and biophysical re | 2026 | 0 |
| The Dual Role of P2RY12: Impact of Polymorphism and Expression on Ischemic Event [PMID:41903930] | Li J, Gong Z, Wang S, Gu J, Wu S, Pang J | Journal of thrombosis and haem | 2026 | 0 |
| Association of P2Y12 Polymorphisms With the Risk of Ischemic Stroke Subtypes. [PMID:41761998] | Wu C, Chen Y, Chen J, Wei X, Zhang Z | Revista de neurologia | 2026 | 0 |
| [Advantageous therapeutic pathways and mechanisms of Jianpi Huogu Formula in tre [PMID:41814722] | Li T, Zhang C, Jia Y, Chen WH, Lin N, Zh | Zhongguo Zhong yao za zhi = Zh | 2026 | 0 |
| Differences in mRNA expression of neuroinflammation-related genes in the tempora [PMID:41843422] | Tan THL, McLean C, Christie M, Sanfilipp | Epileptic disorders : internat | 2026 | 0 |
| Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates A [PMID:41898413] | Paul M, Paul JW, Hinwood M, Hood RJ, Mar | International journal of molec | 2026 | 0 |
| Pan-cancer T cell atlas links a cellular stress response state to immunotherapy [PMID:37248301] | ["Chu Y", "Dai E", "Li Y", "Han G", "Pei | Nature medicine | 2023 | 0 |
| Updates on systemic consequences of coeliac disease. [PMID:33199835] | Katri Kaukinen | Nature reviews. Gastroenterolo | 2021 | 0 |
| Immune-related adverse events predict responses to PD-1 blockade immunotherapy i [PMID:33890283] | ["Lu L", "Xing K", "Wei W", "Ling Y", "L | International journal of cance | 2021 | 0 |
| Homolytic cleavage of diboron(4) compounds using diazabutadiene derivatives. [PMID:34302163] | ["Verma P", "Meher N", "Geetharani K"] | Chemical communications (Cambr | 2021 | 0 |
| Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA [PMID:32461342] | ["Cho S", "Kim S", "Lee Y", "Song E", "K | Journal for immunotherapy of c | 2020 | 0 |
| Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex. [PMID:31780328] | ["Modol L", "Bollmann Y", "Tressard T", | Neuron | 2020 | 0 |
| Stepwise Preparation of a Polymer Comprising Protein Building Blocks on a Solid [PMID:31548440] | ["Miyao H", "Uemura U", "Sueda S"] | Analytical sciences : the inte | 2020 | 0 |
| Blood from heparin tubes is an acceptable alternative to assess hematocrit deter [PMID:30903756] | Pekar Jean-David; Carpentier Thomas; Mab | Clinical chemistry and laborat | 2019 | 0 |
| Excited-state proton transfer relieves antiaromaticity in molecules. [PMID:31554699] | ["Wu C", "Karas L", "Ottosson H", "Wu J" | Proceedings of the National Ac | 2019 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.69 · 2026-04-12
closed · Rounds: 7 · Score: 0.91 · 2026-04-10
Hypotheses and analyses mentioning Purinergic signaling / microglial homeostasis in their description or question text
No additional research found