entity

Prefrontal inhibitory circuits

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Prefrontal inhibitory circuits: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

1Hypotheses

1Analyses

0Outgoing

1Incoming

10Experiments

18Debates

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Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
PVALB	participates_in	gene	0.69

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Prefrontal sensory gating circuit restoration via PV interne	0.775	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 70 hypotheses Top: 0.964

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CHI3L1 variant association with AD progression in human patients	exploratory	Alzheimer's disease	0.850	0.00	human patients	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Integrated multimodal cell atlas of Alzheimer’s disease [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nature Neuroscience	2024	225
Transcriptional and functional profiles of muscarinic receptor-expressing neuron [PMID:41857244]	Tsolias A, Mojica CA, Yamani R, Khanna S	Communications biology	2026	0
Neurophysiological and neuropharmacological effects of melatonin MT2 receptors a [PMID:41571206]	["Barzon B", "Marchiotto F", "Nasini S",	Biochemical pharmacology	2026	0
Enhanced interhemispheric functional connectivity in elderly anxiety patients wi [PMID:41656398]	["Chang Y", "Liu M", "Liu Y", "Xie X", "	Scientific reports	2026	0
Convergent transcriptomic and connectomic controllers of information integration [PMID:41606107]	Luppi AI, Uhrig L, Tasserie J, Mediano P	Nature human behaviour	2026	0
Transcranial direct current stimulation restores addictive behavior via prefront [PMID:41136747]	["Zuo H", "Zhang W", "Wang L", "Wu Y", "	Molecular psychiatry	2026	0
Meta-Analyses of Auditory Evoked Potentials as Alzheimer Biomarkers. [PMID:40836165]	Bayat A, Mirmomeni G, Aiken S, Jafari Z	Ear and hearing	2026	0
Establishing mouse forebrain organoids as models of intrinsic cortical network a [PMID:41791384]	Hernandez S, Schweiger HE, Cline I, Kaur	Stem cell reports	2026	0
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138]	Singer Y, Yitzhaky A, Hertzberg L	Alpha psychiatry	2026	0
A silent Kv channel subunit shapes PV neuron action potential waveform and short [PMID:41632839]	Ganesh S, Canty TM, Sabatini BL	Proceedings of the National Ac	2026	0
Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomati [PMID:41279752]	Mandal P, Trushina E, Arnold M, Kaddurah	bioRxiv : the preprint server	2025	0
Fate plasticity of interneuron specification. [PMID:40264797]	Mostajo-Radji MA, Leon WRM, Breevoort A,	iScience	2025	0
Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Pre [PMID:40426616]	["Liu W", "Li N", "Tang D", "Qin L", "Zh	Brain sciences	2025	0
Medial prefrontal cortex circuit dynamics involved in stage-specific addiction. [PMID:41307570]	["Zhao D", "Zhang X", "Bai J"]	Brain structure & function	2025	0
Studies in rats of a target specific and reversible general anesthetic with a fa [PMID:41187127]	["Xie Z", "Fong R", "Fox A"]	PloS one	2025	0
tDCS-induced enhancement of cognitive flexibility in autism: role of frontal lob [PMID:40874060]	["Han Y", "Dong A", "Xia C", "Zhang Z",	Frontiers in behavioral neuros	2025	0
Fate plasticity of interneuron specification. [PMID:40264797]	["Mostajo-Radji M", "Leon W", "Breevoort	iScience	2025	0
The thalamic reticular nucleus orchestrates social memory. [PMID:38701789]	Wang F, Sun H, Chen M, Feng B, Lu Y, Lyu	Neuron	2024	0
A vagal reflex evoked by airway closure. [PMID:38448588]	["Schappe M", "Brinn P", "Joshi N", "Gre	Nature	2024	0
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024	0