entity

Pericyte loss

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Pericyte loss: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

3Hypotheses

4Analyses

5Outgoing

2Incoming

0Experiments

4Debates

No AI portrait yet

Outgoing (5)

Target	Relation	Type	Str
neuronal dysfunction	causes	phenotype	0.70
Aβ deposition	causes	phenotype	0.70
BBB damage	causes	phenotype	0.70
BBB breakdown	causes	mechanism	0.70
BBB breakdown	causes	mechanism	0.70

Incoming (2)

Source	Relation	Type	Str
sPDGFRβ	biomarker_for	biomarker	0.90
PDGFB haploinsufficiency	causes	process	0.90

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circulating Soluble PDGFRβ Reflects Pericyte Loss and Preced	0.745	-	What blood-brain barrier permeability ch
Circulating Soluble PDGFRβ Reflects Pericyte Loss and Preced	0.625	-	What blood-brain barrier permeability ch
Elevated Circulating sPDGFRβ Reflects Early Pericyte Loss Pr	0.600	-	What blood-brain barrier permeability ch

Mentioning Analyses (4)

Scientific analyses that reference this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.745

Does pericyte senescence drive BBB breakdown or result from neurodegeneration as

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.720

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.605

What is the optimal therapeutic window for microglial reprogramming before irrev

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.735

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Does pericyte senescence drive BBB breakdown or result from neurodegeneration as

closed · Rounds: 4 · Score: 0.68 · 2026-04-25

Multiple hypotheses assumed microglia could be restored to homeostatic states, b

closed · Rounds: 4 · Score: 0.63 · 2026-04-22

While the study establishes P2RY12's role in VSMC foam cell formation in atheros

closed · Rounds: 4 · Score: 0.62 · 2026-04-21

Related Research

Hypotheses and analyses mentioning Pericyte loss in their description or question text

No additional research found