Pathology

The abstract identifies APOE4 association with increased TDP-43 pathology but th

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

AD patients with TDP-43 pathology show worse cognitive impairment, but how TDP-4

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

test debate [TARGET_ARTIFACT type=experiment id=exp-123]

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Cascade in Motor Neuro

Score: 0.678 · neurodegeneration · 2026-04-26

TDP-43 aggregates sequester hepatocyte growth factor-regulated tyrosine kinase substrate (HGS), a critical hub coordinat

Vascular mural cell degeneration precedes and exacerbates parenchymal pathology

Score: 0.649 · Alzheimer's disease · 2026-04-04

## Mechanistic Overview Vascular mural cell degeneration precedes and exacerbates parenchymal pathology starts from the

Age-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Dis

Score: 0.610 · neuroinflammation · 2026-04-22

## Mechanistic Overview Age-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Disease Pathology s

Structure-interacting small molecules that stabilize the APOE4 molten globule do

Score: 0.580 · neuroscience · 2026-04-22

## Mechanistic Overview Structure-interacting small molecules that stabilize the APOE4 molten globule domain (Domain III

Physiological SCFAs may worsen alpha-synuclein pathology through FFAR2/GPR43-NLR

Score: 0.550 · neurodegeneration · 2026-04-24

A key liability hypothesis is that low-range SCFA signaling can be receptor-biased toward inflammasome activation in sus

AAV-mediated RGS6 re-expression in SNpc after pathology onset

Score: 0.530 · neurodegeneration · 2026-04-25

Restore RGS6 in substantia nigra pars compacta dopaminergic neurons after established alpha-synuclein pathology to test

Isoform-Selective Hsp70 Targeting Overcomes Stoichiometric Imbalance in Advanced

Score: 0.481 · protein folding · 2026-04-22

## Mechanistic Overview Isoform-Selective Hsp70 Targeting Overcomes Stoichiometric Imbalance in Advanced Pathology start

Necroptosis-cGAS Feedforward Loop Converts TDP-43 Pathology into Neuroinflammati

Score: 0.460 · neuroinflammation · 2026-04-21

## Mechanistic Overview Necroptosis-cGAS Feedforward Loop Converts TDP-43 Pathology into Neuroinflammation starts from t

Age-dependent downregulation of KPNA2 creates limbic neuron-specific nuclear imp

Score: 0.452 · neurodegeneration · 2026-04-21

## Mechanistic Overview Age-dependent downregulation of KPNA2 creates limbic neuron-specific nuclear import deficiency f

DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed-Forward Loop

Score: 0.430 · neurodegeneration · 2026-04-21

## Mechanistic Overview DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed-Forward Loop starts from the claim

TDP-43 Pathology Creates a Distinct Epigenetic Clock "Signature Divergence" Dete

Score: 0.387 · unknown disease · 2026-04-25

Concise Statement: TDP-43 proteinopathy (as seen in LATE — Limbic-predominant Age-related TDP-43 Encephalopathy) genera

Age-related neuroinflammation mimics early Alzheimer's disease pathology

Score: 0.362 · Alzheimer's disease · 2026-04-23

## Mechanistic Overview Age-related neuroinflammation mimics early Alzheimer's disease pathology starts from the claim t

Gut dysbiosis-driven monocyte reprogramming toward NETotic phenotype accelerates

Score: 0.000 · Alzheimer's disease · 2026-04-27

Intestinal barrier dysfunction and LPS translocation primes CCR2+ circulating monocytes and neutrophils toward a NETosis