gene

PTCH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTCH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Patched 2 - a transmembrane receptor that negatively regulates Hedgehog signaling and plays roles in neural development, stem cell biology, and disease

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🧬 Gene Info

Gene Symbol	PTCH2
Aliases	Patched 2
Chromosome	1p34.1
Protein Type	Receptor
Function	encodes a transmembrane receptor that serves as the primary negative regulator of Hedgehog (Hh) signaling.
Molecular Weight	134 kDa
Amino Acids	207 aa
Exons	23
Ensembl ID	ENSG00000117425
GeneCards	PTCH2
Human Protein Atlas	PTCH2
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PTCH2 Gene

gene · 3361 words

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Pathway Diagram

graph TD
    PTCH2["PTCH2"]
    neurodegeneration["neurodegeneration"]
    PTCH2 -->|"implicated_in"| neurodegeneration
    style PTCH2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PTCH2 in their description or question text

No additional research found