Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PROTEIN KINASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| GFAP | modulates | gene | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Serine/Arginine-Rich Protein Kinase Modulation | 0.624 | neurodegeneration | TDP-43 phase separation therapeutics for |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| s:** - Temporal analysis showing mitochondrial defects precede other p | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| ALS Progression Rate Heterogeneity — mechanism and biomarker predictor | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Development | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-asso [PMID:34614409] | Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, | Cell Metab | 2021 | 1 |
| Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kin [PMID:32169215] | Gou LT, Lim DH, Ma W, Aubol BE, Hao Y, W | Cell | 2020 | 1 |
| ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fert [PMID:23177736] | Zheng G, Dahl JA, Niu Y, Fedorcsak P, Hu | Mol Cell | 2013 | 1 |
| Palmitoylation-Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High-Fa [PMID:41610308] | Tan XH, Li KF, Yuan YM, Xia MC, Zhao FZ | Adv Sci (Weinh) | 2026 | 0 |
| PANTAX: a phase Ib clinical trial of the efflux pump inhibitor SCO-101 in combin [PMID:40272619] | ["Shim S", "Reinacher-Schick A", "Kraeft | Investigational new drugs | 2025 | 0 |
| Potential antitumoral effects of SRPK1 inhibition through modulation of VEGF spl [PMID:41133227] | ["Treppiedi D", "Di Bari S", "Mangili F" | Frontiers in endocrinology | 2025 | 0 |
| Proteome and Phosphoproteome Profiling Reveal the Toxic Mechanism of [PMID:39330852] | ["Yue N", "Huang J", "Dong M", "Li J", " | Toxins | 2024 | 0 |
| Integration of multi-omics transcriptome-wide analysis for the identification of [PMID:39719581] | ["Yi G", "Li Z", "Sun Y", "Ma X", "Wang | Journal of translational medic | 2024 | 0 |
| Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhanci [PMID:36869126] | ["Huang J", "Duan L", "Liu Q", "Li H", " | Oncogene | 2023 | 0 |
| SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alter [PMID:33602301] | ["Liu H", "Gong Z", "Li K", "Zhang Q", " | Journal of experimental & clin | 2021 | 0 |
| SRPK1 is a poor prognostic indicator and a novel potential therapeutic target fo [PMID:30214242] | ["Yi N", "Xiao M", "Jiang F", "Liu Z", " | OncoTargets and therapy | 2018 | 0 |
| Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Glo [PMID:28606917] | ["Lapek J", "Lewinski M", "Wozniak J", " | Molecular & cellular proteomic | 2017 | 0 |
| RNA splicing and splicing regulator changes in prostate cancer pathology. [PMID:28382513] | ["Munkley J", "Livermore K", "Rajan P", | Human genetics | 2017 | 0 |
| Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and v [PMID:28341661] | Ved N, Hulse RP, Bestall SM, Donaldson L | Clinical science (London, Engl | 2017 | 0 |
| MiR-9 regulates the post-transcriptional level of VEGF165a by targeting SRPK-1 i [PMID:25007957] | ["Yoon C", "Kim D", "Kim S", "Park G", " | Graefe's archive for clinical | 2014 | 0 |
| SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment fo [PMID:22817743] | ["Oltean S", "Gammons M", "Hulse R", "Ha | Biochemical Society transactio | 2012 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PROTEIN KINASE in their description or question text
No additional research found