gene

PROKR2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PROKR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PROKR2 Gene - Prokineticin Receptor 2

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🧬 Gene Info

Gene Symbol	PROKR2
Aliases	Page for PROKR2 Gene
Protein Type	Receptor
Function	The PROKR2 gene encodes a 384-amino acid G protein-coupled receptor
Primary Expression	PROKR2 is expressed in dopaminergic neurons of the substantia nigra
Amino Acids	384 aa
UniProt ID	Q8TCW9
Ensembl ID	ENSG00000101292
GeneCards	PROKR2
Human Protein Atlas	PROKR2
Ligand binding	Binds prokineticin-1 (PK1) and prokineticin-2 (PK2) with high affinity
Signal transduction	Couples to Gq proteins, activating PLCbeta and leading to Ca2+ mobilization
Neuroprotection	PK2/PROKR2 signaling has neurotrophic effects and promotes neuron survival
Circadian rhythm	Involved in photic entrainment of circadian clocks
Olfactory function	Important for olfactory bulb development and function
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PROKR2 — AlphaFold Q8TCW9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PROKR2 Gene - Prokineticin Receptor 2

gene · 522 words

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Pathway Diagram

graph TD
    PROKR2["PROKR2"]
    neurodegeneration["neurodegeneration"]
    PROKR2 -->|"implicated_in"| neurodegeneration
    style PROKR2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PROKR2 in their description or question text

No additional research found