gene

PRKACG

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PRKACG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

Gene profile: PRKACG - catalytic subunit gamma of protein kinase A (PKA), a cAMP-dependent serine/threonine kinase critical for synaptic plasticity, memory formation, and neuronal signal transduction. Implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

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🧬 Gene Info

Gene Symbol	PRKACG
Full Name	Protein Kinase A Catalytic Subunit Gamma
Aliases	Gene profile: PRKACG
Chromosome	9p13.3
Function	PKA Target
Subcellular Localization	to the PKA holoenzyme. In the brain, PKA is essential for synaptic plasticity mechanisms underlying learning and memory
UniProt ID	P22694
NCBI Gene ID	55837
GeneCards	PRKACG
Human Protein Atlas	PRKACG
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRKACG — AlphaFold P22694 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRKACG — Protein Kinase A Catalytic Subunit Gamma

gene · 994 words

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Pathway Diagram

graph TD
    PRKACG["PRKACG"]
    neurodegeneration["neurodegeneration"]
    PRKACG -->|"implicated in"| neurodegeneration
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    PRKACG -->|"implicated in"| Alzheimer_S_Disease
    Neurodegenerative_Conditions{"Neurodegenerative Conditions"}
    PRKACG -->|"implicated in"| Neurodegenerative_Conditions
    Parkinson_S_Disease{"Parkinson'S Disease"}
    PRKACG -->|"implicated in"| Parkinson_S_Disease
    Signal_Transduction(["Signal Transduction"])
    PRKACG -->|"regulates"| Signal_Transduction
    Synaptic_Plasticity(["Synaptic Plasticity"])
    PRKACG -->|"regulates"| Synaptic_Plasticity
    style PRKACG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Alzheimer_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neurodegenerative_Conditions fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Synaptic_Plasticity fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Signal_Transduction fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PRKACG in their description or question text

No additional research found