Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPM1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PPM1A |
| Aliases | PP2Cα |
| Chromosome | 14q23.1 |
| Protein Type | Phosphatase |
| Function | GSK3β sites: Ser199, Ser202, Thr231, Ser396, Ser404 |
| Molecular Weight | 39.2 kDa |
| Amino Acids | 382 aa |
| Exons | 8 |
| Pathways | TGF-β signaling, TGF-β Signaling, TGF-β, MAPK Pathway |
| Ensembl ID | ENSG00000163209 |
| GeneCards | PPM1A |
| Human Protein Atlas | PPM1A |
| Catalytic domain | Contains the binuclear metal ion center (Mg2+/Mn2+) |
| N-terminal extension | Regulates substrate specificity |
| Monomeric enzyme | Unlike PP2A, functions without regulatory subunits |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PPM1A["PPM1A"]
neurodegeneration["neurodegeneration"]
PPM1A -->|"implicated_in"| neurodegeneration
style PPM1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PPM1A in their description or question text
No additional research found