Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PIKFYVE Inhibition: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| sGPNMB | upregulates | biomarker | 0.95 |
| Amyotrophic Lateral Sclerosis | treats | disease | 0.90 |
| autophagosome-lysosome fusion | inhibits | mechanism | 0.90 |
| ER stress response | activates | mechanism | 0.90 |
| cytoplasmic vacuolation | causes | phenotype | 0.90 |
| ALS | treats | disease | 0.90 |
| disease progression | associated_with | phenotype | 0.88 |
| neurodegeneration | suppresses | process | 0.85 |
| Diverse Forms of ALS | protects_against | disease | 0.85 |
| cellular toxicity | associated_with | phenotype | 0.82 |
| lysosomal_function | associated_with | phenotype | 0.70 |
| Tau Pathology | inhibits | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| sGPNMB | biomarker_for | biomarker | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5 | 0.584 | neurodegeneration | How does PIKFYVE inhibition activate unc |
| C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by | 0.562 | neurodegeneration | How does PIKFYVE inhibition activate unc |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.584
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| PPP3/calcineurin-dependent TFEB dephosphorylation mechanism | exploratory | motoneuron degeneration | 0.800 | 0.00 | neuronal cell lines | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.64 · 2026-04-16
closed · Rounds: 4 · Score: 0.63 · 2026-04-13
Hypotheses and analyses mentioning PIKFYVE Inhibition in their description or question text
No additional research found