gene

PIK3R6

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PIK3R6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PIK3R6 Gene

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🧬 Gene Info

Gene Symbol	PIK3R6
Full Name	Phosphoinositide-3-Kinase Regulatory Subunit 6
Chromosome	17p13.1
Function	is a class IB PI3K predominantly expressed in leukocytes but also detected in neurons and glial cells.
Primary Expression	leukocytes but also detected in neurons and glial cells
Pathways	PI3K
UniProt ID	Q9NRA8
NCBI Gene ID	27137
Ensembl ID	ENSG00000110676
OMIM	607270
GeneCards	PIK3R6
Human Protein Atlas	PIK3R6
SH2 domains	Two src homology 2 domains for phosphotyrosine binding
iSH2 domain	Inter-SH2 domain for dimerization with catalytic subunit
p110γ binding	Forms heterodimer with PI3K catalytic subunit p110γ
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PIK3R6 — AlphaFold Q9NRA8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PIK3R6 Gene

gene · 943 words

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Pathway Diagram

graph TD
    PIK3R6["PIK3R6"]
    neurodegeneration["neurodegeneration"]
    PIK3R6 -->|"implicated_in"| neurodegeneration
    style PIK3R6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning PIK3R6 in their description or question text

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