protein

PERIPHERIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERIPHERIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for Peripherin Protein

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🔬 Protein Info

Gene Symbol	PERIPHERIN
Protein Family	Intermediate filament protein family
Function	is a protein encoded by the PRPH gene.
Primary Expression	peripheral neurons and a subset of central nervous system neurons[@portier1993]
Subcellular Localization	Cytoplasm, Neuronal intermediate filaments
Molecular Weight	57 kDa
Amino Acids	4477 aa
UniProt ID	P17656
GeneCards	PERIPHERIN
Human Protein Atlas	PERIPHERIN
Neuronal development	Forms heteropolymeric intermediate filament networks with neurofilaments during axonal growth and myelination[@nixon2000]
Axonal transport	Associates with microtubule-based transport machinery through interactions with dynein/dynactin complexes[@shea1989]
Synaptic plasticity	Localizes to synaptic compartments and may regulate presynaptic vesicle dynamics[@parhad1995]
Neuronal integrity	Provides structural stability to axons, particularly in peripheral sensory and motor neurons[@elder1998]
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PERIPHERIN — AlphaFold P17656 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Peripherin Protein

protein · 843 words

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Pathway Diagram

graph TD
    PERIPHERIN["PERIPHERIN"]
    neurodegeneration["neurodegeneration"]
    PERIPHERIN -->|"implicated_in"| neurodegeneration
    style PERIPHERIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PERIPHERIN in their description or question text

No additional research found