Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDCD10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PDCD10 (CCM3) is a gene associated with Cerebral Cavernous Malformation and has roles in apoptosis, cell signaling, and neuroprotection.
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| Gene Symbol | PDCD10 |
| Chromosome | 3q26.1 |
| Function | The protein is evolutionarily conserved across species, from zebrafish to humans, indicating its fundamental role in cellular physiology[@ncbi]. |
| Primary Expression | the central nervous system, where it plays important roles in neuronal survival, synaptic function, and neuroprotection |
| Subcellular Localization | the cytoplasm and associated with cellular membranes, where it participates in various signaling cascades that regulate |
| Amino Acids | 212 aa |
| UniProt ID | Q8WU39 |
| NCBI Gene ID | 11235 |
| Ensembl ID | ENSG00000128604 |
| GeneCards | PDCD10 |
| Human Protein Atlas | PDCD10 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PDCD10["PDCD10"]
neurodegeneration["neurodegeneration"]
PDCD10 -->|"implicated_in"| neurodegeneration
style PDCD10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PDCD10 in their description or question text
No additional research found