gene

PANK4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PANK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

0Debates

Summary

Pantothenate Kinase 4 - PANK4 - involved in coenzyme A biosynthesis and ciliary function, implicated in ciliopathies and potentially in neurodegenerative processes

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🧬 Gene Info

Gene Symbol	PANK4
Full Name	Pantothenate Kinase 4
Chromosome	1p36.22
Function	The enzyme catalyzes the first and rate-limiting step in the coenzyme A (CoA) biosynthetic pathway: the phosphorylation of vitamin B5 (pantothenate) to produce 4'-phosphopantothenate.
Primary Expression	various brain regions:
Subcellular Localization	PANK4 is primarily cytosolic but also localizes to specific cellular compartments including basal bodies of cilia. This
Amino Acids	248 aa
Ensembl ID	ENSG00000155040
GeneCards	PANK4
Human Protein Atlas	PANK4
Cerebral cortex	Moderate expression in pyramidal neurons
Hippocampus	Expression in CA regions and dentate gyrus
Cerebellum	Purkinje cells show detectable expression
Choroid plexus	High expression in this ciliated epithelial tissue
Associated Diseases	Alzheimer's Disease, Cognitive Trajectory, Pantothenate Kinase-Associated Neurodegeneration
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PANK4 Gene

gene · 1757 words

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Pathway Diagram

flowchart TD
    PANK4(["PANK4"])
    Coenzyme_A("Coenzyme A")
    Skeletal_Muscle_Substrate_Metabolism("Skeletal Muscle Substrate Metabo...")
    AKT(["AKT"])
    Pantothenate_Kinase_Associated_Neurodege["Pantothenate Kinase-Associated N..."]
    Alzheimer_s_Disease["Alzheimer's Disease"]
    Cognitive_Trajectory("Cognitive Trajectory")
    neurodegeneration["neurodegeneration"]

    PANK4 -->|"regulates"| Coenzyme_A
    PANK4 -->|"associated with"| Skeletal_Muscle_Substrate_Metabolism
    AKT -->|"regulates"| PANK4
    PANK4 -->|"implicated in"| Pantothenate_Kinase_Associated_Neurodege
    PANK4 -->|"associated with"| Alzheimer_s_Disease
    PANK4 -->|"associated with"| Cognitive_Trajectory
    PANK4 -->|"implicated in"| neurodegeneration

    style PANK4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
Coenzyme A	regulates	biological_process	0.80
Skeletal Muscle Substrate Metabolism	associated_with	biological_process	0.80
Pantothenate Kinase-Associated Neurodegeneration	implicated_in	disease	0.70
Cognitive Trajectory	associated_with	phenotype	0.70
Alzheimer's Disease	associated_with	disease	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PANK4 in their description or question text

No additional research found