Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PAK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PAK3 |
| Full Name | p21-Activated Kinase 3 |
| Protein Type | Kinase |
| Function | encodes a member of the Group I p21-activated kinases, a family of serine/threonine kinases that function as key regulators of cytoskeletal dynamics, cell motility, and synaptic function. |
| Primary Expression | the brain, where it plays essential roles in neuronal development, dendritic arborization, spine formation, and synaptic plasticity |
| Molecular Weight | 65 kDa |
| Amino Acids | 580 aa |
| Exons | 16 |
| Ensembl ID | ENSG00000177239 |
| GeneCards | PAK3 |
| Human Protein Atlas | PAK3 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PAK3["PAK3"]
neurodegeneration["neurodegeneration"]
PAK3 -->|"implicated_in"| neurodegeneration
style PAK3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PAK3 in their description or question text
No additional research found