Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Osmotic Gradient: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| water transport | drives | process | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Cotransporters | interacts_with | protein | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Osmotic Gradient Restoration via Selective AQP1 Enhancement | 0.680 | neurodegeneration | Perivascular spaces and glymphatic clear |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co | clinical | Alzheimer's Disease | 0.900 | 0.50 | aortic endothelial cells | proposed | $6,550,000 |
| CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| AQP1 differentially orchestrates endothelial cell senescence. [PMID:39180980] | Shabanian K, Shabanian T, Karsai G, Pont | Redox Biol | 2024 | 1 |
| Non-Aquaporin Water Channels. [PMID:36717505] | Huang B, Wang H, Yang B | Adv Exp Med Biol | 2023 | 1 |
| Aquaporins in Nervous System. [PMID:28258567] | Xu M, Xiao M, Li S, Yang B | Adv Exp Med Biol | 2017 | 1 |
| Aquaporins in the Spinal Cord. [PMID:27941618] | Oklinski MK, Skowronski MT, Skowronska A | Int J Mol Sci | 2016 | 1 |
| Aquaporin gating. [PMID:16837191] | Hedfalk K, Törnroth-Horsefield S, Nyblom | Curr Opin Struct Biol | 2006 | 1 |
| Panax notoginseng saponins protect the blood-brain barrier against oxidative str [PMID:41763432] | Fan L, Qu S, Miao C, Wu D, Rao Y et al. | Int J Biol Macromol | 2026 | 0 |
| Stomatin encapsulates aquaporin-1 and urea transporter-B in the erythrocyte memb [PMID:41921000] | Vallese F, Li H, Barazzuol L, Calì T, Cl | Sci Adv | 2026 | 0 |
| Aquaporin membrane channels in the hepatobiliary tract: a model of complexity an [PMID:41926019] | Portincasa P, Khalil M, Calamita G | Intern Emerg Med | 2026 | 0 |
| Glycosomal Aquaglyceroporin 1 dual role in iron homeostasis and antimony suscept [PMID:41926379] | Boy RL, Zampieri RA, Aoki JI, Coelho AC, | PLoS Negl Trop Dis | 2026 | 0 |
| Aquaporin-1 Facilitates Macrophage M1 Polarization by Enhancing Glycolysis Throu [PMID:39365391] | ["Diao R", "Lv W", "Wang Y", "Shen Q", " | Inflammation | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. [PMID:34670044] | Morelle J, Marechal C, Yu Z, Debaix H, C | The New England journal of med | 2021 | 0 |
| Discovery of novel diarylamides as orally active diuretics targeting urea transp [PMID:33532188] | ["Zhang S", "Zhao Y", "Wang S", "Li M", | Acta pharmaceutica Sinica. B | 2021 | 0 |
| Physiological and pathological impact of AQP1 knockout in mice. [PMID:31023968] | Hua Y, Ying X, Qian Y, Liu H, Lan Y, Xie | Bioscience reports | 2019 | 0 |
| The potential role of aquaporin 1 on aristolochic acid I induced epithelial mese [PMID:29215709] | ["Li J", "Zhang M", "Mao Y", "Li Y", "Zh | Journal of cellular physiology | 2018 | 0 |
| Cardiotrophin-1 predicts death or heart failure following acute myocardial infar [PMID:17045183] | ["Khan S", "Kelly D", "Quinn P", "Davies | Journal of cardiac failure | 2006 | 0 |
| Regulation of mitosis in response to damaged or incompletely replicated DNA requ [PMID:16079276] | ["Purdy A", "Uyetake L", "Cordeiro M", " | Journal of cell science | 2005 | 0 |
| Physiological roles of aquaporins in the choroid plexus. [PMID:15949534] | Boassa D, Yool AJ | Current topics in developmenta | 2005 | 0 |
| Structural basis of ion pumping by Ca2+-ATPase of the sarcoplasmic reticulum. [PMID:15189143] | ["Toyoshima C", "Inesi G"] | Annual review of biochemistry | 2004 | 0 |
| Su e of the yeast F1Fo-ATP synthase forms homodimers. [PMID:12377768] | ["Brunner S", "Everard-Gigot V", "Stuart | The Journal of biological chem | 2002 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Osmotic Gradient in their description or question text
No additional research found