Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OSK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| epigenetic clock reset | causes | process | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Reelin-Mediated Cytoskeletal Stabilization Protocol | 0.689 | neurodegeneration | Selective vulnerability of entorhinal co |
| Partial OSK Reprogramming Reverses Epigenetic Aging Without | 0.630 | neurodegeneration | Investigate mechanisms of epigenetic rep |
| Profilin-1 Cytoskeletal Checkpoint Enhancement | 0.554 | neurodegeneration | Gene expression changes in aging mouse b |
| Epigenetic Reprogramming Required for Late-Stage Interventio | 0.542 | neurodegeneration | What is the optimal therapeutic window f |
| AAV-PHP.eB-Medium OSK Expression Reverses Cortical Neuronal | 0.520 | neurodegeneration | epigenetic reprogramming aging neurons |
| Cytoskeletal Transport Selectivity Enhancement | 0.455 | neurodegeneration | How do host cell factors influence the c |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-10 | 7 hypotheses Top: 0.700
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| REL transcription factor mediates VLC ceramide-driven inflammation | exploratory | inflammation | 0.750 | 0.00 | innate immune cells | proposed | N/A |
| Levodopa Response Determinants in PSP — Biomarker-Guided Prediction St | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Neural Stem Cell Therapy for Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction. [PMID:39892386] | Vandal M, Institoris A, Reveret L, Korin | Neuron | 2025 | 1 |
| Protective genetic variants against Alzheimer's disease. [PMID:40409316] | Marino C, Malotaux V, Giudicessi A, Agui | Lancet Neurol | 2025 | 1 |
| Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional [PMID:39232006] | Serafin DS, Harris NR, Bálint L, Douglas | Nat Commun | 2024 | 1 |
| Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Devel [PMID:32604886] | Jossin Y | Biomolecules | 2020 | 1 |
| Neuronal migration. [PMID:11429281] | Lambert de Rouvroit C, Goffinet AM | Mech Dev | 2001 | 1 |
| Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, a [PMID:41858499] | ["Barger S", "Moerman-Herzog A"] | Frontiers in molecular neurosc | 2026 | 0 |
| The Potential Molecular Mechanisms and Key Genes of Early Deterioration of Paren [PMID:41863408] | ["Cen G", "Li J", "Wang J", "Chen Y", "L | Current neurovascular research | 2026 | 0 |
| RELN biallelic variant as a candidate risk factor in a consanguineous Pakistani [PMID:41785923] | ["Hashmi A", "Harripaul R", "Muhammad T" | Journal of affective disorders | 2026 | 0 |
| Silibinin inhibits F-actin assembly leading to G2/M cell cycle arrest in human b [PMID:41349910] | Fu J, Liu S, Zhao R, Liu W, Hayashi T et | Biochem Pharmacol | 2026 | 0 |
| Small molecule intervention of actin-binding protein profilin1 reduces tumor ang [PMID:41386296] | Gau D, Chawla P, Xu K, Welling N, Antone | J Biol Chem | 2026 | 0 |
| F-Box and Leucine-Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity an [PMID:41589689] | Li X, He X, Hao X, Zhang Y, Zhao X et al | Adv Sci (Weinh) | 2026 | 0 |
| APOE4-driven T cell dysregulation in Alzheimer's disease: single-cell genomics a [PMID:41673758] | Zheng D, Gu J, Nao J, Sun M, Dong X | J Neuroinflammation | 2026 | 0 |
| Proteomic analysis of plasma extracellular vesicles for predicting acute kidney [PMID:41720883] | Li J, Xu L, Liu Y, Liu X, Li X et al. | Sci Rep | 2026 | 0 |
| Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052] | Burdman Gabriel; Akkaoui Juliet; Colon N | Neurology international | 2026 | 0 |
| Profillin-1 and Transgelin-2: Actin Binding Proteins Expression in Early and Adv [PMID:41911947] | Shahid MA, Mushtaq S, Khan A, Naseeb U, | Cancer Rep (Hoboken) | 2026 | 0 |
| Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Fo [PMID:41677619] | ["Smith M", "Natarajan E", "Lizama-Valen | Cells | 2026 | 0 |
| Migration of dI5 Reelin-Lmx1b-Zfhx3 and Disabled-1-Lmx1b-Zfhx3 neurons contribut [PMID:41890024] | ["Yvone G", "Chavez-Martinez C", "Mekonn | bioRxiv : the preprint server | 2026 | 0 |
| Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler [PMID:41844513] | ["Simanaviciute U", "Cetin A", "Guy J", | Genes, brain, and behavior | 2026 | 0 |
| Reln haploinsufficiency enhances fentanyl-induced locomotion and striatal activi [PMID:41890027] | ["Litif C", "Libster A", "Desfor S", "Hu | bioRxiv : the preprint server | 2026 | 0 |
| Immunoglobulin allotypes and [PMID:41848375] | ["Pandey J", "Namboodiri A", "Nietert P" | Journal of Alzheimer's disease | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-21
closed · Rounds: 0 · Score: 0.48 · 2026-04-21
closed · Rounds: 0 · Score: 0.51 · 2026-04-21
closed · Rounds: 4 · Score: 0.73 · 2026-04-21
Hypotheses and analyses mentioning OSK in their description or question text