protein

OPA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for OPA3 Protein

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🔬 Protein Info

Gene Symbol	OPA3
Full Name	OPA3 mitochondrial outer membrane protein
Chromosome	19q13.32
Function	The OPA3 gene (Optic Atrophy 3) encodes a mitochondrial outer membrane protein that plays critical roles in mitochondrial dynamics, cellular metabolism, and neuronal survival.
Subcellular Localization	the mitochondrial outer membrane, where it participates in mitochondrial fusion, cristae maintenance, and regulation of
Amino Acids	179 aa
UniProt ID	[Q9H3K1](https://www.uniprot.org/uniprot/Q9H3K1)
Ensembl ID	ENSG00000142046
GeneCards	OPA3
Human Protein Atlas	OPA3
Lipid metabolism	Influences cardiolipin distribution
Iron-sulfur cluster assembly	Connected to Fe-S cluster biogenesis
Cellular stress response	Activated under mitochondrial stress
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

OPA3 Gene

gene · 667 words

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OPA3 Protein

protein · 1022 words

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Pathway Diagram

graph TD
    OPA3["OPA3"]
    neurodegeneration["neurodegeneration"]
    OPA3 -->|"implicated_in"| neurodegeneration
    style OPA3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning OPA3 in their description or question text

No additional research found