Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ntkr3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NTKR3 |
| Protein Type | Receptor |
| Function | NTRK3 encodes TrkC (Tropomyosin receptor kinase C), the primary receptor for neurotrophin-3 (NT-3). |
| Primary Expression | both the developing and adult nervous system, with roles in neuronal differentiation, process extension, synapse formation, and survival |
| Ensembl ID | ENSG00000140538 |
| GeneCards | NTKR3 |
| Human Protein Atlas | NTKR3 |
| PLC-γ Pathway | Phospholipase C-gamma activation leads to IP3/DAG signaling and calcium release |
| PI3K/Akt Pathway | Promotes cell survival through Akt phosphorylation |
| RAS/MAPK Pathway | Regulates gene expression, cell differentiation, and synaptic plasticity |
| Sensory Neuron Development | NT-3 is essential for the development of proprioceptive and certain sensory neurons |
| Sympathetic Neurons | Supports the development and survival of sympathetic ganglion neurons |
| Central Nervous System | NT-3 promotes differentiation of specific CNS neuronal populations |
| Muscle Innervation | NT-3 from muscle regulates the formation of neuromuscular junctions |
| Synaptic Formation | NT-3 promotes the formation of excitatory synapses |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["ntkr3 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:NTKR3 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:NTKR3 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ntkr3 in their description or question text
No additional research found