Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ntkr2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NTKR2 |
| Protein Type | Receptor |
| Function | NTRK2 encodes TrkB (Tropomyosin receptor kinase B), the primary receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). |
| Primary Expression | both the developing and adult nervous system, where it supports neuronal survival, process outgrowth, synapse formation, and plasticity |
| Ensembl ID | ENSG00000157184 |
| GeneCards | NTKR2 |
| Human Protein Atlas | NTKR2 |
| PLC-γ Pathway | Phospholipase C-gamma activation leads to IP3/DAG signaling and calcium release. This pathway regulates synaptic plasticity and gene expression |
| PI3K/Akt Pathway | Promotes cell survival through Akt phosphorylation, inhibiting pro-apoptotic proteins. Critical for neuronal survival |
| RAS/MAPK Pathway | Regulates gene expression, cell differentiation, synaptic plasticity, and long-term memory formation |
| cAMP/PKA Pathway | Modulates ion channel function and gene transcription |
| Long-term Potentiation (LTP) | BDNF release during high-frequency stimulation activates TrkB, enhancing glutamate receptor function and spine growth |
| Long-term Depression (LTD) | TrkB signaling also contributes to LTD, depending on the context and receptor isoform |
| Synaptic Strength | TrkB activation modulates the strength of both excitatory and inhibitory synapses |
| Spine Morphogenesis | TrkB signaling promotes the formation and maintenance of dendritic spines |
| Associated Diseases | depression: |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["ntkr2 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:NTKR2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:NTKR2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ntkr2 in their description or question text
No additional research found