Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NDUFC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NDUFC2 encodes a core subunit of mitochondrial complex I, essential for NADH oxidation and electron transport, implicated in Parkinson's disease and mitochondrial disorders
No AI portrait yet
| Gene Symbol | NDUFC2 |
| Full Name | NADH:Ubiquinone Oxidoreductase Core Subunit C2 |
| Chromosome | 11q14.1 |
| Function | encodes a critical component of mitochondrial complex I (NADH:ubiquinone oxidoreductase), the largest enzyme of the mitochondrial respiratory chain. |
| Molecular Weight | 13.5 kDa |
| Amino Acids | 119 aa |
| UniProt ID | [O95299](https://www.uniprot.org/uniprot/O95299) |
| Ensembl ID | ENSG00000100983 |
| GeneCards | NDUFC2 |
| Human Protein Atlas | NDUFC2 |
| Peripheral arm | Extends into the matrix, contains the NADH oxidation site and all iron-sulfur clusters |
| Membrane arm | Contains the proton-pumping modules and the ubiquinone binding site |
| Associated Diseases | Parkinson's disease |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NDUFC2["NDUFC2"]
neurodegeneration["neurodegeneration"]
NDUFC2 -->|"implicated_in"| neurodegeneration
style NDUFC2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NDUFC2 in their description or question text
No additional research found