Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Microglial Memory: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | risk_factor_for | process | 0.90 |
| Neurodegeneration Susceptibility | biomarker_for | phenotype | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Microglial Polarization | contributes_to | process | 0.85 |
| Inflammation | modulates | process | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte-Mediated Microglial Memory Erasure | 0.677 | - | Neuroinflammation and microglial priming |
| PGE2–EP2–cAMP–PKA Axis Displaces Pathological Microglial Mem | 0.649 | neuroinflammation | What specific astrocyte-derived factors |
| Epigenetic Reprogramming of Microglial Memory | 0.647 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
| Morphological characterization of microglial states in human brain | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression a [PMID:40752494] | Liu Z, Zhang S, James BT, Galani K, Mang | Cell | 2025 | 1 |
| Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical [PMID:38678292] | Oosthoek M, Vermunt L, de Wilde A, Bonge | Alzheimer's research & therapy | 2024 | 1 |
| Detailed stratified GWAS analysis for severe COVID-19 in four European populatio [PMID:35848942] | Degenhardt F, Ellinghaus D, Juzenas S, L | Human molecular genetics | 2022 | 1 |
| Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Hom [PMID:29548672] | Datta M, Staszewski O, Raschi E, Frosch | Immunity | 2018 | 1 |
| Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines [PMID:26746105] | Herbert J, Lucassen PJ | Frontiers in neuroendocrinolog | 2016 | 1 |
| Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042] | ["Lyu G", "Li D"] | CNS & neurological disorders d | 2026 | 0 |
| Obstructive sleep apnea, biomarker profiles, and clinical progression in Parkins [PMID:41499940] | Zhu S, An D, Liu X | Sleep Med | 2026 | 0 |
| Systemic inflammation and its associations in acute moderate-severe Traumatic Br [PMID:41623670] | Li LM, Kodosaki E, Xu CJY, Heslegrave A, | Brain Behav Immun Health | 2026 | 0 |
| Time-dependent neurovascular unit dysfunction in ischemic stroke: mechanisms of [PMID:41642667] | Lahariya R, Sinha M, Kumari B, Subramani | Int J Neurosci | 2026 | 0 |
| Integrative Proteomics Reveal Neuroimmune and Dopaminergic Alterations Across th [PMID:41677653] | Majumdar S, Prajapati SK, Dande A, Yata | Cells | 2026 | 0 |
| Astroglial and Neuronal Injury Markers (GFAP, UCHL-1, NfL, Tau, S100B) as Diagno [PMID:41828591] | Ogłodek EA, Bar M | Int J Mol Sci | 2026 | 0 |
| Interconnected roles of astrocytes and the blood-brain barrier in Parkinson's di [PMID:41868432] | Stoll AC, Harms AS | Front Aging Neurosci | 2026 | 0 |
| Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia rev [PMID:32941599] | Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li | The Journal of experimental me | 2020 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Microglial Memory in their description or question text
No additional research found