Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Microglial Glycolysis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | contributes_to | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HK2 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Metabolic Reprogramming via Microglial Glycolysis Inhibition | 0.672 | neurodegeneration | Synaptic pruning by microglia in early A |
| Dysregulated microglial glycolysis via HIF1α activation shif | 0.520 | neurodegeneration | Synaptic pruning by microglia in neurode |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | completed | $100,000 |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | completed | $80,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Saturation mutagenesis of twenty disease-associated regulatory elements at singl [PMID:31395865] | ["Kircher M", "Xiong C", "Martin B", "Sc | Nature Communications | 2019 | 267 |
| Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-d [PMID:41520557] | Sun B, Zhang A, Feng S, Jamali AW, Jia Z | Int Immunopharmacol | 2026 | 1 |
| HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352] | Pesce NA, Seminara G, Giarrusso G, Tomas | Adv Biol (Weinh) | 2026 | 1 |
| Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285] | Fang M, Zhou Y, He K, Lu Y, Tao F, Huang | Mol Neurobiol | 2025 | 1 |
| Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroin [PMID:40911376] | Sun L, Wang X, Guan S, Zhang P, Chen D, | FASEB J | 2025 | 1 |
| The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014] | Fontana F, Giannitti G, Marchesi S, Limo | Int J Biol Sci | 2024 | 1 |
| AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated [PMID:39217289] | Zhou J, Zhang J, Xu F, Gao H, Wang L, Zh | Mol Med | 2024 | 1 |
| Hexokinase 2-mediated gene expression via histone lactylation is required for he [PMID:37463576] | Rho H, Terry AR, Chronis C, Hay N | Cell Metab | 2023 | 1 |
| Crosstalk Between [PMID:41899603] | ["Ren Y", "Tang D", "Ding X", "He M"] | Cancers | 2026 | 0 |
| Modulation of Aerobic Glycolysis Genes During the Progression of Retinitis Pigme [PMID:41569027] | ["Adani E", "Villa Vasquez S", "Lovino M | Investigative ophthalmology & | 2026 | 0 |
| Duzhong-Gegen formula ameliorated hyperuricemia by enhancing renal uric acid exc [PMID:41905095] | Wang L, Gan Y, Huang J, Long L, Li S, Wa | Phytomedicine : international | 2026 | 0 |
| Mitophagy bridges glucose metabolism, inflammation and neuroprotection in astroc [PMID:41677100] | ["Hakansson H", "Howden J", "Kittler J"] | Autophagy | 2026 | 0 |
| Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular De [PMID:41897347] | ["Xiao T", "Tao J", "Tan J", "Yi X", "Wa | Biomolecules | 2026 | 0 |
| STING Degradation by PRRSV Activates HK2-Mediated Glycolysis to Facilitate Viral [PMID:41902192] | Luo L, Zhou L, Gao X, Li Y, Zhou H, Li Y | Viruses | 2026 | 0 |
| Multifunctional Engineered Metal-Organic Frameworks as Targeted Protein Degrader [PMID:41924308] | ["Li S", "Liu R", "Zhang Q", "Sun J", "H | Research (Washington, D.C.) | 2026 | 0 |
| Erchen decoction and its active flavonoids hesperidin and quercetin alleviate hi [PMID:41921767] | Zheng M, Yang K, Ma Y, Suo W, Li J, Huan | Journal of ethnopharmacology | 2026 | 0 |
| Quercetin Attenuates Iron Overload-Induced Renal Injury via Activating Nrf2/xCT/ [PMID:41900891] | ["Wang X", "Li W", "Yuan W", "Wei Z", "Y | Life (Basel, Switzerland) | 2026 | 0 |
| FOXP1 deficiency exacerbates cellular senescence in PM [PMID:41916119] | ["Chen H", "Zhan Z", "Lu M", "Li D", "Pe | Ecotoxicology and environmenta | 2026 | 0 |
| STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by [PMID:37443289] | Zhang L, Jiang C, Zhong Y, Sun K, Jing H | Nature cell biology | 2023 | 0 |
| Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage p [PMID:35246504] | Jiang H, Wei H, Wang H, Wang Z, Li J, Ou | Cell death & disease | 2022 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Microglial Glycolysis in their description or question text
No additional research found