entity

Male

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Male: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

6Hypotheses

1Analyses

2Outgoing

0Incoming

0Experiments

1Debates

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Outgoing (2)

Target	Relation	Type	Str
Autonomic Regulation	associated_with	process	0.90
ALS	associated_with	disease	0.85

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
X-Linked KDM6A Escapes X-Inactivation to Drive Female-Biased	0.675	Alzheimer disease	Sex-Specific Microglial States in Amyloi
Female microglia exhibit heightened complement gene expressi	0.610	neurodegeneration	Synaptic pruning by microglia in neurode
Female Microglia Exhibit Reduced P2Y12 Expression Conferring	0.580	neuroinflammation	How do regional, age, and sex-dependent
CX3CR1-Negative Trem2-High Microglial Subset Mediates Female	0.570	neuroinflammation	How do regional, age, and sex-dependent
Neurodevelopmental Sex Differences in Thalamocortical GluN2B	0.526	neuroscience	GluN2B-Mediated Thalamocortical Control

Testosterone-Derived DHT Amplifies Microglial Androgen Recep	0.490	neuroinflammation	How do regional, age, and sex-dependent

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

endocrinology | 2026-04-13 | 2 hypotheses Top: 0.653

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Despite FDA warnings and a 315% increased erythrocytosis risk with TRT, the asso

closed · Rounds: 4 · Score: 0.83 · 2026-04-14

Related Research

Hypotheses and analyses mentioning Male in their description or question text

Testosterone-Derived DHT Amplifies Microglial Androgen Receptor Signaling Drivin

Score: 0.490 · neuroinflammation · 2026-04-22

## Mechanistic Overview Testosterone-Derived DHT Amplifies Microglial Androgen Receptor Signaling Driving Male-Biased Ne