Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MYH8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MYH8 encodes the perinatal myosin heavy chain, a muscle-specific contractile protein expressed during development and in muscle regeneration, with implications for neuromuscular diseases.
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| Gene Symbol | MYH8 |
| Full Name | Myosin Heavy Chain 8 |
| Chromosome | 17p13.1 |
| Protein Family | Myosin heavy chain family |
| Function | is a member of the myosin heavy chain family, a group of motor proteins that generate contractile force in muscle cells through ATP-dependent interaction with actin filaments. |
| Primary Expression | human skeletal muscle |
| Molecular Weight | 224 kDa |
| Amino Acids | 930 aa |
| Exons | 38 |
| Pathways | MAPK, PI3K/Akt |
| UniProt ID | Q7Z4W2 |
| NCBI Gene ID | 4626 |
| Ensembl ID | ENSG00000133116 |
| OMIM | 160741 |
| GeneCards | MYH8 |
| Human Protein Atlas | MYH8 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MYH8["MYH8"]
neurodegeneration["neurodegeneration"]
MYH8 -->|"implicated_in"| neurodegeneration
style MYH8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MYH8 in their description or question text
No additional research found