protein

MUNC131

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about MUNC131: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	MUNC13
Full Name	1 Protein
Aliases	MUNC131
Function	MUNC13-1 (UNC13A) is a massive presynaptic protein essential for synaptic vesicle priming and neurotransmitter release[@cclrantes].
Subcellular Localization	</b></td><td>Presynaptic active zone</td></tr>
GeneCards	MUNC13
Human Protein Atlas	MUNC13
Gene therapy approaches	Viral vector delivery to restore proper UNC13A expression
Synaptic modulators	Compounds that enhance MUNC13-1 function or compensate for its loss
ASO therapy	Antisense oligonucleotides to modulate UNC13A expression
Protein-protein interaction inhibitors	Targeting interactions that may be pathogenic
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MUNC13-1 Protein

protein · 1135 words

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Pathway Diagram

graph TD
    MUNC131["MUNC131"]
    neurodegeneration["neurodegeneration"]
    MUNC131 -->|"implicated_in"| neurodegeneration
    style MUNC131 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Related Research

Hypotheses and analyses mentioning MUNC131 in their description or question text

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