Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MSH3, PMS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| MT-ND1, MT-ND4, MT-ND6 | co_associated_with | gene | 0.40 |
| SOD1, TARDBP, BDNF, GDNF, IGF-1 | co_associated_with | gene | 0.40 |
| SIRT1, FOXO3, NRF2, TFAM | co_associated_with | gene | 0.40 |
| UBE3A, PARK2, PINK1 | co_associated_with | gene | 0.40 |
| SOD1, HTT, TARDBP | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi | 0.681 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.827
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604] | Casazza KM, Williams GM, Johengen L, Kel | bioRxiv | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning MSH3, PMS1 in their description or question text
No additional research found