Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Tau Protein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Microtubule-associated protein tau (MAPT gene) stabilizes neuronal microtubules and facilitates axonal transport. Tau is normally soluble and intracellular, but hyperphosphorylation causes detachment from microtubules and aggregation into paired helical filaments and neurofibrillary tangles. Tau pathology spreads in a stereotypical pattern (Braak stages I-VI) from the transentorhinal cortex to the hippocampus and neocortex, correlating closely with cognitive decline in Alzheimer disease. Tau aggregates also characterize frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration.
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| Gene Symbol | MICROTUBULE |
| Full Name | ASSOCIATED PROTEIN TAU |
| GeneCards | MICROTUBULE |
| Human Protein Atlas | MICROTUBULE |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPT | encodes | gene | 0.99 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Tau Protein in their description or question text
No additional research found