protein

MGLUR8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MGLUR8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

Metabotropic glutamate receptor 8 (mGluR8/GRM8) is a Group III GPCR functioning as a presynaptic inhibitory autoreceptor with high glutamate affinity, critically involved in regulating excitatory neurotransmission and synaptic plasticity in cortical and limbic circuits.

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🔬 Protein Info

Gene Symbol	MGLUR8
Aliases	mGluR8/GRM8
Chromosome	7q31.3
Protein Type	Receptor
Function	mGluR8 is a Group III metabotropic glutamate receptor functioning as a presynaptic autoreceptor in cortical and hippocampal regions.
Molecular Weight	105 kDa
Exons	9
GeneCards	MGLUR8
Human Protein Atlas	MGLUR8
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR8 Protein

protein · 744 words

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Pathway Diagram

graph TD
    MGLUR8["MGLUR8"]
    neurodegeneration["neurodegeneration"]
    MGLUR8 -->|"implicated in"| neurodegeneration
    Synaptic_Plasticity(["Synaptic Plasticity"])
    MGLUR8 -->|"regulates"| Synaptic_Plasticity
    GLUTAMATE["GLUTAMATE"]
    MGLUR8 ---|"interacts"| GLUTAMATE
    style MGLUR8 fill:#1a4a3a,stroke:#81c784,stroke-width:3px,color:#fff
    style Synaptic_Plasticity fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MGLUR8 in their description or question text

No additional research found