Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MARS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MARS2 encodes mitochondrial arginyl-tRNA synthetase 2, an enzyme essential for mitochondrial protein synthesis. Mutations cause hereditary spastic paraplegia and mitochondrial disorders, with implications for neurodegeneration.
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| Gene Symbol | MARS2 |
| Full Name | Mitochondrial Arginyl-tRNA Synthetase 2 |
| Chromosome | 2q33.1 |
| Protein Type | Synthetase |
| Function | encodes a mitochondrial aminoacyl-tRNA synthetase (mtARS) that specifically charges arginine to its cognate mitochondrial tRNA. |
| Primary Expression | tissues with high mitochondrial energy demands: |
| Molecular Weight | 65 kDa |
| Amino Acids | 577 aa |
| UniProt ID | [Q9N3W4](https://www.uniprot.org/uniprot/Q9N3W4) |
| Ensembl ID | ENSG00000135953 |
| GeneCards | MARS2 |
| Human Protein Atlas | MARS2 |
| Length | Approximately 577 amino acids |
| Molecular weight | ~65 kDa |
| Domains | Contains the catalytic domain typical of class I aminoacyl-tRNA synthetases |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MARS2["MARS2"]
neurodegeneration["neurodegeneration"]
MARS2 -->|"implicated_in"| neurodegeneration
style MARS2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MARS2 in their description or question text
No additional research found