gene

MAPK13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

MAPK13 encodes p38 delta, a stress-activated kinase with roles in neuroinflammation, dopaminergic neuron survival, and ischemic neuronal death.

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🧬 Gene Info

Gene Symbol	MAPK13
Full Name	Mitogen-Activated Protein Kinase 13
Protein Type	Serine/Threonine Kinase
Function	is a serine/threonine kinase belonging to the p38 MAPK family.
Primary Expression	epithelial cells, neurons, and immune cells[@cuadrado2016]
Pathways	MAPK
Ensembl ID	ENSG00000156787
GeneCards	MAPK13
Human Protein Atlas	MAPK13
STAT1	transcriptional regulation in inflammation
MSK1/2	chromatin remodeling and gene expression
CREB	activity-dependent neuronal gene regulation
HSP27	cytoskeletal dynamics and cell survival
Brain	hippocampus, cerebral cortex, substantia nigra, cerebellum
Epidermis	keratinocytes (high expression)
Associated Diseases	Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAPK13 — Mitogen-Activated Protein Kinase 13

gene · 738 words

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Pathway Diagram

graph TD
    MAPK13["MAPK13"]
    neurodegeneration["neurodegeneration"]
    MAPK13 -->|"implicated_in"| neurodegeneration
    style MAPK13 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning MAPK13 in their description or question text

No additional research found