gene

MAP3K2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about MAP3K2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	MAP3K2
Full Name	Mitogen-Activated Protein Kinase Kinase Kinase 2
Chromosome	2q14.3
Protein Type	Kinase
Function	is a serine/threonine protein kinase that plays critical roles in activating the MAPK signaling cascades.
Pathways	MAPK signaling, MAPK
UniProt ID	[Q9Y252](https://www.uniprot.org/uniprot/Q9Y252)
Ensembl ID	ENSG00000167060
OMIM	607389
GeneCards	MAP3K2
Human Protein Atlas	MAP3K2
Cytoplasmic	Majority of protein in resting state
Membrane-associated	Upon activation via receptor signaling
Nuclear	Subset translocates to nucleus for gene regulation
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAP3K2 — Mitogen-Activated Protein Kinase Kinase Kinase 2

gene · 1838 words

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Pathway Diagram

graph TD
    MAP3K2["MAP3K2"]
    neurodegeneration["neurodegeneration"]
    MAP3K2 -->|"implicated_in"| neurodegeneration
    style MAP3K2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning MAP3K2 in their description or question text

No additional research found