gene

MAP2K3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP2K3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for MAP2K3 - Mitogen-Activated Protein Kinase Kinase 3

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🧬 Gene Info

Gene Symbol	MAP2K3
Full Name	Mitogen-Activated Protein Kinase Kinase 3
Aliases	Page for MAP2K3
Chromosome	6p21.3
Protein Type	Kinase
Function	is a dual-specificity protein kinase that serves as a critical upstream activator of the p38 MAPK signaling pathway.
Primary Expression	both neurons and glial cells, where its activation contributes to neuroinflammation, tau pathology, and synaptic
Molecular Weight	38 kDa
Amino Acids	347 aa
Exons	10
Pathways	MAPK signaling, MAPK, NF-κB
UniProt ID	[P46734](https://www.uniprot.org/uniprot/P46734)
Ensembl ID	ENSG00000099695
GeneCards	MAP2K3
Human Protein Atlas	MAP2K3
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MAP2K3 - Mitogen-Activated Protein Kinase Kinase 3

gene · 797 words

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MAP2K3 Protein (MEK3)

protein · 2447 words

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Pathway Diagram

graph TD
    MAP2K3["MAP2K3"]
    neurodegeneration["neurodegeneration"]
    MAP2K3 -->|"implicated_in"| neurodegeneration
    style MAP2K3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00

Incoming (1)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAP2K3 in their description or question text

No additional research found