gene

MAN2B1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAN2B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

2Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for MAN2B1 Gene

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🧬 Gene Info

Gene Symbol	MAN2B1
Full Name	Mannosidase Alpha Class 2B Member 1
Chromosome	19q13.13
Function	The MAN2B1 gene encodes acid alpha-mannosidase, a lysosomal hydrolase that catalyzes the hydrolysis of terminal alpha-mannose residues from mannose-containing oligosaccharides.
Primary Expression	most tissues, with highest levels in:
Molecular Weight	280 kDa
UniProt ID	O00754
NCBI Gene ID	4125
Ensembl ID	ENSG00000112837
OMIM	604458
GeneCards	MAN2B1
Human Protein Atlas	MAN2B1
Inheritance Pattern	Autosomal recessive
Prevalence	~1 in 500,000 to 1 in 1,000,000 births
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAN2B1 — AlphaFold O00754 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAN2B1 Gene

gene · 583 words

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Pathway Diagram

graph TD
    MAN2B1["MAN2B1"]
    TREM2["TREM2"]
    MAN2B1 -->|"associated with"| TREM2
    oxidized_phosphatidylcholines["oxidized phosphatidylcholines"]
    MAN2B1 -->|"associated with"| oxidized_phosphatidylcholines
    neurodegeneration["neurodegeneration"]
    MAN2B1 -->|"implicated in"| neurodegeneration
    style MAN2B1 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7

Outgoing (2)

Target	Relation	Type	Str
TREM2	associated_with	gene	0.80
oxidized phosphatidylcholines	associated_with	chemical	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAN2B1 in their description or question text

No additional research found