gene

LRRTM4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about LRRTM4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

LRRTM4 (Leucine-Rich Repeat Transmembrane Neuronal 4) is a synaptic adhesion molecule involved in excitatory synapse development, sensory processing, and neurodevelopmental disorders including ASD and intellectual disability.

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🧬 Gene Info

Gene Symbol	LRRTM4
Full Name	Leucine-Rich Repeat Transmembrane Neuronal 4
Chromosome	12p13.31
Function	is a synaptic adhesion molecule that plays a critical role in excitatory synapse formation, development, and function.
Primary Expression	Brain (cortex, hippocampus, sensory cortices)
Molecular Weight	68 kDa
Amino Acids	677 aa
UniProt ID	Q9HCK5
NCBI Gene ID	66037
Ensembl ID	ENSG00000145860
OMIM	611243
GeneCards	LRRTM4
Human Protein Atlas	LRRTM4
Associated Diseases	Autism
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LRRTM4 — AlphaFold Q9HCK5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LRRTM4 Gene

gene · 2534 words

→

LRRTM4 Protein

protein · 584 words

→

Pathway Diagram

graph TD
    LRRTM4["LRRTM4"]
    neurodegeneration["neurodegeneration"]
    LRRTM4 -->|"implicated_in"| neurodegeneration
    style LRRTM4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LRRTM4 in their description or question text

No additional research found