Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRRTM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LRRTM3 (Leucine-Rich Repeat Transmembrane Neuronal 3) is a synaptic adhesion molecule involved in excitatory synapse formation, implicated in Alzheimer's disease and autism spectrum disorder.
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| Gene Symbol | LRRTM3 |
| Full Name | Leucine-Rich Repeat Transmembrane Neuronal 3 |
| Chromosome | 10q21.3 |
| Function | is a synaptic adhesion molecule that plays a critical role in excitatory synapse formation and function. |
| Primary Expression | visual processing regions and contributes to retinogeniculate connectivity |
| Molecular Weight | 65 kDa |
| Amino Acids | 523 aa |
| UniProt ID | Q86VH5 |
| NCBI Gene ID | 285220 |
| Ensembl ID | ENSG00000163220 |
| OMIM | 611242 |
| GeneCards | LRRTM3 |
| Human Protein Atlas | LRRTM3 |
| Signal Peptide (1-20 aa) | N-terminal secretion signal that directs the protein to the secretory pathway |
| Transmembrane Region (401-423 aa) | Single-pass membrane anchor |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
LRRTM3["LRRTM3"]
neurodegeneration["neurodegeneration"]
LRRTM3 -->|"implicated_in"| neurodegeneration
style LRRTM3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LRRTM3 in their description or question text
No additional research found