Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRP1-Dependent Tau Uptake Disruption: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LRP1 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| LRP1-Dependent Tau Uptake Disruption | 0.808 | neurodegeneration | Tau propagation mechanisms and therapeut |
| LRP1-Dependent Tau Uptake Disruption | 0.576 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susce | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients | proposed | N/A |
| Endothelial CD2AP knockdown effects on memory in male mice | validation | Alzheimer's disease | 0.900 | 0.00 | male mice | proposed | N/A |
| HDAC4 inhibition and NHE6 expression mechanism study | exploratory | Alzheimer's disease | 0.850 | 0.00 | proposed | N/A | |
| Network Pharmacology Analysis of Shared AD Targets | exploratory | Alzheimer's disease | 0.850 | 0.00 | Computational network analysis | proposed | N/A |
| MRI Phenotyping Method Concordance in Serbian AD Cohort | clinical | Alzheimer's disease | 0.850 | 0.00 | human patients | proposed | N/A |
| Endothelin-1 receptor A antagonist rescue in male CD2AP mice | validation | Alzheimer's disease | 0.850 | 0.00 | male mice | proposed | N/A |
| Neuroimmune modulation and Aβ clearance mechanisms | exploratory | Alzheimer's disease | 0.820 | 0.00 | Microglia and astrocytes | proposed | N/A |
| CD2AP expression and cognitive decline in AD patients | exploratory | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| Competing endogenous RNA (ceRNA) network construction | exploratory | Alzheimer's disease | 0.750 | 0.00 | computational network analysis | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Insulin-like growth factor-1 enhances β-amyloid protein clearance in HMC3 microg [PMID:41621577] | Guo H, Peng X, Zhang X, Ruganzu JB, Wu X | Experimental cell research | 2026 | 0 |
| Osteoclast-secreted galectin-3 promotes articular cartilage degeneration in OVX [PMID:40609733] | Chen L, Hong H, Yang Z, Zhong Y, Sun S e | Osteoarthritis Cartilage | 2026 | 0 |
| Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877] | Miao J, Wang J, Zhou W, Guo J | Sci Rep | 2026 | 0 |
| Lysosomal trafficking markers covering PSAP, PGRN, SORT1 and LRP1 in body liquid [PMID:41579784] | Poniatowski ŁA, Siwińska A, Acewicz A, K | Forensic science international | 2026 | 0 |
| Mitochondrial calcium uniporter knockdown in hippocampal neurons effectively att [PMID:41687804] | Wu L, Hou F, Wang Z, Wu M, Wang X, Cao J | Experimental neurology | 2026 | 0 |
| Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS m [PMID:40595262] | Sagulkoo P, Chuntakaruk H, Suratanee A, | Scientific reports | 2025 | 0 |
| Inhibition of tau neuronal internalization using anti-tau single domain antibodi [PMID:40175345] | ["Danis C", "Dupr\u00e9 E", "Bouillet T" | Nature communications | 2025 | 0 |
| Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial [PMID:41430102] | Gong Z, Zhang M, Liu N, Asam K, Martellu | The journal of headache and pa | 2025 | 0 |
| Ganglioside sialylation modulates tau internalization and pathology spread. [PMID:41398374] | Li S, Chen Y, Song T, Liu D, Wu R, Yang | Molecular psychiatry | 2025 | 0 |
| Microglia internalize tau monomers and fibrils using distinct receptors but simi [PMID:39713861] | Falkon KF, Danford L, Gutierrez Kuri E, | Alzheimer's & dementia : the j | 2025 | 0 |
| Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain isc [PMID:38906140] | Zhou J, Zhang L, Peng J, Zhang X, Zhang | Cell metabolism | 2024 | 0 |
| Mitochondrial NADK2-dependent NADPH controls Tau oligomer uptake in human neuron [PMID:39554169] | Pardo E, Kim T, Wallrabe H, Zengeler KE, | bioRxiv : the preprint server | 2024 | 0 |
| The role of neutrophils in tPA thrombolysis after stroke: a malicious troublemak [PMID:39606238] | Li Q, Ye J, Li Z, Xiao Q, Tan S, Hu B, J | Frontiers in immunology | 2024 | 0 |
| Editorial for “Corrected <scp>MRI</scp> Pulmonary Transit Time for Identificatio [PMID:36029232] | Ricci Fabrizio; Khanji Mohammed Y; Garg | Journal of Magnetic Resonance | 2023 | 0 |
| Ancient gene linkages support ctenophores as sister to other animals. [PMID:37198475] | ["Schultz D", "Haddock S", "Bredeson J", | Nature | 2023 | 0 |
| Pan-cancer T cell atlas links a cellular stress response state to immunotherapy [PMID:37248301] | ["Chu Y", "Dai E", "Li Y", "Han G", "Pei | Nature medicine | 2023 | 0 |
| PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by ma [PMID:36797420] | Schilperoort M, Ngai D, Katerelos M, Pow | Nature metabolism | 2023 | 0 |
| Amyloidosis in Alzheimer's Disease: Pathogeny, Etiology, and Related Therapeutic [PMID:35209007] | Ma C, Hong F, Yang S | Molecules (Basel, Switzerland) | 2022 | 0 |
| Incidence of Chronic Obstructive Pulmonary Disease in People With Human Immunode [PMID:34260725] | ["Ronit A", "Omland L", "Kronborg G", "P | The Journal of infectious dise | 2022 | 0 |
Multi-agent debates referencing this entity