protein

LINGO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LINGO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Leucine-Rich Repeat and Immunoglobulin-Like Domain-Containing Neurite Outgrowth Inhibitor Protein - a key negative regulator of axonal regeneration and myelination

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🔬 Protein Info

Gene Symbol	LINGO1
Chromosome	19p13.3
Protein Type	Protein
Function	is a transmembrane receptor protein that plays a critical role in the central nervous system (CNS) as a negative regulator of axonal regeneration, myelination, and synaptic plasticity.
Primary Expression	the CNS, where it coordinates signaling pathways that control neural development, oligodendrocyte function, and neuronal survival
Molecular Weight	63 kDa
Amino Acids	581 aa
UniProt ID	Search UniProt
GeneCards	LINGO1
Human Protein Atlas	LINGO1
Oligodendrocytes	Pre-myelinating and mature oligodendrocytes
Neurons	Particularly in cortical and hippocampal neurons
Astrocytes	Subpopulations of astrocytes in gray matter
Microglia	Low-level expression in activated microglia
Inhibits differentiation	Blocks the transition from OPC to mature oligodendrocyte
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: LINGO1 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LINGO1 Protein

protein · 2117 words

→

LINGO1 — Leucine-Rich Repeat and Immunoglobulin-Like Domain-Containing Neurite Outgrowth Inhibitor Protein

gene · 761 words

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Pathway Diagram

graph TD
    LINGO1["LINGO1"]
    neurodegeneration["neurodegeneration"]
    LINGO1 -->|"implicated_in"| neurodegeneration
    style LINGO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning LINGO1 in their description or question text

No additional research found