gene

KLC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KLC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

1Outgoing

2Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	KLC1
Full Name	Kinesin Light Chain 1
Chromosome	16q23.2
Function	encodes a component of the kinesin-1 motor complex that is essential for intracellular transport along microtubules in neurons.
Subcellular Localization	axons and dendrites, where it participates in the transport of diverse cargoes critical for synaptic function and neuron
Molecular Weight	65 kDa
Amino Acids	609 aa
Exons	13
GeneCards	KLC1
Human Protein Atlas	KLC1
Isoform 1	Full-length protein (609 aa)
Isoform 2	Lacks exon 9, missing a portion of the TPR domain
Isoform 3	Alternative N-terminus
Associated Diseases	neurodegeneration
Interactions	HNRNPA2B1
KG Connections	3 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KLC1 — Kinesin Light Chain 1

gene · 2601 words

→

Pathway Diagram

graph TD
    KLC1["KLC1"]
    IRS1["IRS1"]
    KLC1 -->|"binds"| IRS1
    neurodegeneration["neurodegeneration"]
    KLC1 -->|"implicated in"| neurodegeneration
    ACETYL_L_CARNITINE["ACETYL-L-CARNITINE"]
    ACETYL_L_CARNITINE -->|"upregulates"| KLC1
    style KLC1 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7

Outgoing (1)

Target	Relation	Type	Str
IRS1	binds	protein	0.90

Incoming (2)

Source	Relation	Type	Str
ACETYL-L-CARNITINE	upregulates	drug	0.70
HNRNPA2B1	interacts_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KLC1 in their description or question text

No additional research found